GW284543

GW284543 (UNC10225170) is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].

Product Specifications

CAS Number

[790186-68-4]

Product Name Alternative

UNC10225170

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MEK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gw284543.html

Purity

99.94

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

COC1=CC2=C(NC3=CC(OC4=CC=CC=C4)=CC=C3)C=CN=C2C=C1OC

Molecular Formula

C23H20N2O3

Molecular Weight

372.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34 (5) :807-822.e7.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MEK5

Available Sizes

Curated Selection

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