GW284543
Product Specifications
Product Name Alternative
(S)-(+)-Abscisic acid; ABA
UNSPSC Description
GW284543 (UNC10225170) is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].
Target Antigen
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gw284543.html
Purity
99.94
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
COC1=CC2=C(NC3=CC(OC4=CC=CC=C4)=CC=C3)C=CN=C2C=C1OC
Molecular Weight
372.42
References & Citations
[1]Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114189/GW284543-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114189/GW284543-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
790186-68-4
Available Sizes
Curated Selection
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