Tau Antibody, Clone 3D4

Tau is a microtubule-associated protein predominantly found in neuronal axons, where it stabilizes microtubules and supports axonal transport. In the adult human brain, six isoforms of tau are expressed, generated by alternative splicing of the MAPT gene. These isoforms contain either three (3R) or four (4R) microtubule-binding repeat domains, with 2N4R (Tau-441) representing the full-length form. In healthy neurons, tau is tightly regulated. However, in neurodegenerative diseases known as tauopathies—including Alzheimer’s disease (AD), frontotemporal dementia, and progressive supranuclear palsy—tau becomes abnormally hyperphosphorylated. This modification reduces its affinity for microtubules, leading to the formation of insoluble neurofibrillary tangles (NFTs), a pathological hallmark of AD. Mutations in the MAPT gene, such as P301S (encoded by exon 10), impair tau’s ability to bind microtubules and promote aggregation. These mutations are commonly used in transgenic models to study tau-mediated neurotoxicity, synaptic dysfunction, and neuronal death. Tau pathology correlates strongly with cognitive decline in AD and is increasingly recognized as a driver of disease progression. As such, tau is a major focus of biomarker development and therapeutic targeting in neurodegenerative research.

Tau, TAU, TAU_HUMAN, MAPT, MAPTL, Microtubule-associated protein tau, Microtubule associated protein tau, Microtubule associated protein tau isoform 4, Neurofibrillary tangle protein, Paired helical filament tau, Paired helical filament-tau, PHF tau, PHF-tau, DDPAC, FTDP 17, G protein beta1/gamma2 subunit interacting factor 1, MSTD, Mtapt, MTBT1, MTBT2, PPND, PPP1R103, Protein phosphatase 1 regulatory subunit 103, RNPTAU, AI413597, AW045860, FLJ31424, MGC134287, MGC138549, MGC156664

Cytoplasm | Axolemma | Axolemma Plasma Membrane | Axon | Cell Body | Cell membrane | Cytoplasmic Ribonucleoprotein Granule | Cytoplasmic Side | Cytoskeleton | Cytosol | Dendrite | Growth cone | Microtubule | Microtubule Associated Complex | Neurofibrillary Tangle | Neuronal Cell Body | Nuclear Periphery | Nuclear Speck | Nucleus | Peripheral membrane protein | Plasma Membrane | Tubulin Complex

Alzheimer's Disease | Axon Markers | Cell Markers | Cell Signaling | Cytoskeleton | Microtubules | MT Associated Proteins | Neurodegeneration | Neuron Markers | Neuroscience | Tangles & Tau

A 1:1000 dilution of SMC-608 was sufficient for detection of Tau 2N4R P301S Fibril in 20 ug of Mouse Brain by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

1. www.alz.org/alzheimers-dementia/facts-figures 2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907) 3. Matsumoto, G. et al. (2018). Int J Mol Sci. 19, 1497. 4. Goedert, M. and Spillantini, M. G. (2017). Mol Brain. 10:18. 5. Bugiani, O. et al. (1999). J Neuropathol Exp Neurol. 58(6):667-77.

1. www.alz.org/alzheimers-dementia/facts-figures 2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907) 3. Matsumoto, G. et al. (2018) . Int J Mol Sci. 19, 1497. 4. Goedert, M. and Spillantini, M. G. (2017) . Mol Brain. 10:18. 5. Bugiani, O. et al. (1999) . J Neuropathol Exp Neurol. 58 (6) :667-77.

Cytoplasm | Axolemma | Axolemma Plasma Membrane | Axon | Cell Body | Cell membrane | Cytoplasmic Ribonucleoprotein Granule | Cytoplasmic Side | Cytoskeleton | Cytosol | Dendrite | Growth cone | Microtubule | Microtubule Associated Complex | Neurofibrillary Tangle | Neuronal Cell Body | Nuclear Periphery | Nuclear Speck | Nucleus | Peripheral membrane protein | Plasma Membrane | Tubulin Complex