Alpha Synuclein Antibody (pSer129), Clone J18: PerCP

Alpha-synuclein (SNCA) is a neuronal protein predominantly expressed in the brain, where it is enriched at presynaptic terminals and plays a key role in synaptic function (1) . It is also highly expressed in mitochondria-rich regions such as the olfactory bulb, hippocampus, striatum, and thalamus, suggesting a role in mitochondrial dynamics and neuronal energy metabolism (2) . Functionally, alpha-synuclein interacts with tubulin (3), indicating a potential role as a microtubule-associated protein involved in cytoskeletal organization and intracellular transport. It is essential for cognitive development, with SNCA inactivation linked to impaired spatial learning and working memory (4) . Pathologically, SNCA aggregates are a major non-Aβ component of amyloid plaques in Alzheimer’s disease and a defining feature of Lewy body inclusions in Parkinson’s disease (PD) . PD is characterized by the progressive accumulation of alpha-synuclein and ubiquitin-positive inclusions in vulnerable neurons, contributing to neurodegeneration (5, 6) . Critically, phosphorylation of alpha-synuclein at serine 129 (pSer129) is a key post-translational modification associated with disease pathology. Approximately 90% of alpha-synuclein found in Lewy bodies is phosphorylated at Ser129, compared to only a small fraction in the healthy brain (7, 8) . This modification is widely used as a biomarker for pathological alpha-synuclein and is a focal point in therapeutic and diagnostic research targeting synucleinopathies.

Alpha Synuclein, α-Synuclein, SNCA, alphaSYN, NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Phosphorylated alpha synuclein, Phospho-alpha Synuclein (S129), Alpha-synuclein (phospho S129), Alpha Synuclein (phospho Ser129), Alpha-Synuclein Phospho Ser129, phospho-α-Synuclein (Ser129), Alpha Synuclein phospho Serine 129, Alpha Synuclein phospho Ser 129, Alpha Synuclein pSerine 129, Alpha Synuclein pSer 129, Alpha Synuclein phosphoSer 129, isoform NACP140, PARK1, PARK 1, PARK4, PARK 4, Parkinson disease (autosomal dominant, Lewy body) 4, Parkinson disease familial 1, SYN, Synuclein alpha, Synuclein alpha 140, Synuclein, alpha (non A4 component of amyloid precursor), SYUA_HUMAN

Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.

Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein | Neuroscience | Neurodegeneration | Multiple System Atrophy

A 1:500 dilution of SMC-600 was sufficient for detection of Alpha Synuclein pSer129 in 10 µg of Mouse Brain by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.

1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van’kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757. 7. Fujiwara H., et al. (2002) Nat Cell Biol. 4(2):160-4. 8. Anderson J.P., et al. (2006) J Biol Chem. 281(40):29739-52.

1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013) . 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277 (3) : 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van’kin G. (2012) Behav. Brain. Res. 231 (1) : 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388 (6645) : 839-840. 6. Mezey E., et al. (1998) Nat Med. 4 (7) : 755-757. 7. Fujiwara H., et al. (2002) Nat Cell Biol. 4 (2) :160-4. 8. Anderson J.P., et al. (2006) J Biol Chem. 281 (40) :29739-52.