Parvalbumin Antibody, Clone C12

Mouse Anti-Rat Parvalbumin Monoclonal IgG2a

Product Specifications

Background

Parvalbumin is a calcium-binding protein predominantly expressed in fast-spiking GABAergic interneurons. It plays a crucial role in buffering intracellular calcium and regulating neuronal excitability and synaptic timing. Alterations in parvalbumin-expressing interneurons have been implicated in a range of neurological and psychiatric disorders, including Alzheimer’s disease, schizophrenia, autism spectrum disorders, and age-related cognitive decline. Loss of parvalbumin function disrupts inhibitory signaling, leading to network hyperexcitability and impaired cognitive processing. As a marker of interneuron health and circuit integrity, parvalbumin is a valuable target for studying neural dysfunction and developing interventions aimed at restoring excitatory-inhibitory balance in the brain.

CAS Number

9007-83-4

Specifications

Detects 12 kDa.

Product Name Alternative

Parvalbumin alpha, PRVA_HUMAN, PVALB

Synonyms

parvalbumin Antibody, Clone C12

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

25269

Swiss Prot

P02625

Accession Number

NP_071944.1

Cellular Locus

Cytoplasmic vesicle membrane

Host

Mouse

Species Reactivity

Human,Rat,Mouse

Immunogen

Synthetic peptide from the full length Rat Parvalbumin protein

Target

parvalbumin

Clonality

Monoclonal

Isotype

IgG2a

Clone

C12

Conjugation

Unconjugated

Tissue Specificity

Retina. Expressed throughout the horizontal cells and/or terminals.

Type

Monoclonal

Applications

WB | ICC/IF | ELISA | IHC

Validated Applications

WB,ICC/IF,ELISA,IHC

Field of Research

Neuroscience | Neurotransmission | Calcium Signaling

Purification

Protein A Purified

Limit Of Detection

A 1:500 dilution of SMC-563 was sufficient for detection of Parvalbumin in 15 ug of Rat Brain by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1mg/ml

Dilution

WB (1:500) ; IHC (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Cates. M.S., Teodoro M.L., Phillips G.N. (2002) Biophys J. 82(3): 1133-1146.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects 12 kDa.

Background Reference 01

1. Cates. M.S., Teodoro M.L., Phillips G.N. (2002) Biophys J. 82 (3) : 1133-1146.

Species

Human | Rat | Mouse

Location

Cytoplasmic vesicle membrane

Isotype

IgG2a

Immunogen Species

Rat

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