Metallothionein Antibody, Clone 8D8

Mouse Anti-Pseudomonas aeruginosa Metallothionein Monoclonal IgG1

Product Specifications

Background

Metallothioneins (MTs) are low-molecular-weight, cysteine-rich proteins that bind heavy metals and scavenge reactive oxygen species (ROS) . In the brain, MTs play a critical role in maintaining metal ion homeostasis, particularly for zinc and copper, and in protecting neurons from oxidative damage. Elevated expression of MTs in astrocytes and microglia has been observed in response to neurotoxic insults, including inflammation, ischemia, and protein aggregation. Their antioxidant and anti-inflammatory properties make MTs key players in the defense against neurodegenerative processes in Alzheimer’s, Parkinson’s, and prion diseases. Enhancing MT expression or mimicking their function may offer therapeutic benefits by mitigating oxidative stress and preserving neuronal integrity.

CAS Number

9007-83-4

Specifications

Detects 36 kDa band corresponding to Pseudomonas aeruginosa Metallothionein.

Product Name Alternative

Metallothionein, Metallothionein 1A, Metallothionein 1S, Metallothionein IA, Metallothionein II, Metallothionein-1A, Metallothionein-IA, Metallothionein2, Metallothionein 2, Metallothionein 2A, MT1, MT1A, MT1S, MT2, MT2A, MT 1A, MT IA, MT II, MT-1A, MT-IA, MT1A_HUMAN, MGC32848, MTC, pmtA, Probable Metallothionein, CES 1, CES1

Synonyms

Metallothionein Antibody, Clone 8D8

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

880550

Swiss Prot

Q9I1X5

Accession Number

NP_250830.1

Host

Mouse

Species Reactivity

P. aeruginosa

Immunogen

Recombinant full length Pseudomonas aeruginosa Metallothionein protein

Target

Metallothionein

Clonality

Monoclonal

Isotype

IgG1

Clone

8D8

Conjugation

Unconjugated

Type

Monoclonal

Applications

WB | ELISA

Validated Applications

WB,ELISA

Field of Research

Cell Signaling | Epigenetics and Nuclear Signaling | Transcription | Domain Families | Zinc finger

Purification

Protein G Purified

Limit Of Detection

A 1:1000 dilution of SMC-553 was sufficient for detection of Metallothionein in 1 µg of purified Pseudomonas aeruginosa Metallothionein (PmtA) -GST tagged protein by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000) ; ELISA (1:800) ; optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects 36 kDa band corresponding to Pseudomonas aeruginosa Metallothionein.

Species

Bacteria (Pseudomonas aeruginosa)

Isotype

IgG1

Immunogen Species

Pseudomonas aeruginosa

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