ZSET1446
ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.
Product Specifications
CAS Number
887603-94-3
Product Name Alternative
ST-101
UNSPSC
12352005
Target
Calcium Channel; nAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/ZSET1446.html
Purity
98.01
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N=C2C=CC=CN2C13CC4=C(C=CC=C4)C3
Molecular Formula
C15H12N2O
Molecular Weight
236.27
References & Citations
[1]Takeda K, et al. Potentiation of Acetylcholine-Mediated Facilitation of Inhibitory Synaptic Transmission by an Azaindolizione Derivative, ZSET1446 (ST101), in the Rat Hippocampus. J Pharmacol Exp Ther. 2016 Feb;356 (2) :445-55|[2]Yamaguchi Y, et al. Combination effects of ZSET1446/ST101 with memantine on cognitive function and extracellular acetylcholine in the hippocampus. J Pharmacol Sci. 2013;123 (4) :347-55. Epub 2013 Nov 29.|[3]Yamaguchi Y, et al. Effects of ZSET1446/ST101 on cognitive deficits and amyloid β deposition in the senescence accelerated prone mouse brain. J Pharmacol Sci. 2012;119 (2) :160-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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