PROTAC SMARCA2/4-degrader-26

PROTAC SMARCA2/4-degrader-26 (compound 6) is a PROTAC targeting SMARCA2/4. SMARCA2 and SMARCA4 are genes and cancer targets with complementary functions that catalyze nucleosome movement. PROTAC SMARCA2/4-degrader-25 is composed of PROTAC target protein ligand 2- (4- (3-Amino-6- (2-hydroxyphenyl) pyridazin-4-yl) piperazin-1-yl) acetic acid (HY-46618) (red part), E3 ligase ligand (2S,4R) -4-Hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide (HY-W998248) (blue part), PROTAC linker (S) -2-Amino-3,3-dimethylbutanoic acid (HY-59140) (black part), and the conjugate composed of E3 ubiquitin ligase ligand + Linker is (S, R, S) -AHPC (HY-125845) [1].

Product Specifications

UNSPSC

12352211

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-smarca2-4-degrader-26.html

Smiles

O=C([C@H]1N(C([C@@H](NC(CN2CCN(C3=CC(C4=CC=CC=C4O)=NN=C3N)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

Molecular Formula

C38H47N9O5S

Molecular Weight

741.90

References & Citations

[1]Ji M, et al. Glutathione-dependent degradation of SMARCA2/4 for targeted lung cancer therapy with improved selectivity. Eur J Med Chem. 2024 Nov 5;277:116751.