PROTAC SMARCA2/4-degrader-26
PROTAC SMARCA2/4-degrader-26 (compound 6) is a PROTAC targeting SMARCA2/4. SMARCA2 and SMARCA4 are genes and cancer targets with complementary functions that catalyze nucleosome movement. PROTAC SMARCA2/4-degrader-25 is composed of PROTAC target protein ligand 2- (4- (3-Amino-6- (2-hydroxyphenyl) pyridazin-4-yl) piperazin-1-yl) acetic acid (HY-46618) (red part), E3 ligase ligand (2S,4R) -4-Hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide (HY-W998248) (blue part), PROTAC linker (S) -2-Amino-3,3-dimethylbutanoic acid (HY-59140) (black part), and the conjugate composed of E3 ubiquitin ligase ligand + Linker is (S, R, S) -AHPC (HY-125845) [1].
Product Specifications
UNSPSC
12352211
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-4-degrader-26.html
Smiles
O=C([C@H]1N(C([C@@H](NC(CN2CCN(C3=CC(C4=CC=CC=C4O)=NN=C3N)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
Molecular Formula
C38H47N9O5S
Molecular Weight
741.90
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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