Hexanoyl-Lysine adduct Antibody, Clone 5E8

Hexanoyl-lysine adduct (HEL) is a lipid peroxidation marker formed by the reaction of oxidized fatty acids with lysine residues on proteins. It serves as an early indicator of oxidative stress, a central feature in the pathogenesis of neurodegenerative diseases. In the brain, HEL accumulation reflects damage to neuronal membranes and proteins caused by reactive oxygen species (ROS) . Elevated levels of HEL have been detected in models of Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative conditions, correlating with disease progression and cognitive decline. HEL is particularly valuable as a biomarker due to its stability and specificity for lipid peroxidation. Its presence indicates oxidative damage at an early stage, often preceding overt neurodegeneration. This makes HEL a promising candidate for early diagnosis, disease monitoring, and evaluating the efficacy of antioxidant therapies. By highlighting the oxidative component of neurodegeneration, HEL contributes to a deeper understanding of disease mechanisms and supports the development of targeted interventions aimed at reducing oxidative injury in the nervous system.

Specific for Hexanoyl-Lysine adduct (HEL) modified peptides and proteins. Does not detect free Hexanoyl-Lysine. Does not cross-react with Acrolein, Crotonaldehyde, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, Malondialdehyde, or Methylglyoxal modified proteins.

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A 1:1000 dilution of SMC-509 was sufficient for detection of Hexanoyl Lysine adduct in 0.5 µg of Hexanoyl Lysine conjugated to BSA by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary Antibody.

Specific for Hexanoyl-Lysine adduct (HEL) modified peptides and proteins. Does not detect free Hexanoyl-Lysine. Does not cross-react with Acrolein, Crotonaldehyde, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, Malondialdehyde, or Methylglyoxal modified proteins.