NPAS4 Antibody, Clone N408/79: RPE

NPAS4 (Neuronal PAS Domain Protein 4) is a brain-specific transcription factor that plays a pivotal role in regulating activity-dependent gene expression critical for synaptic plasticity, learning, and memory. As a member of the bHLH-PAS family, NPAS4 is rapidly induced by neuronal activity and orchestrates the formation and maintenance of inhibitory synapses, particularly in excitatory neurons. NPAS4 modulates the excitatory-inhibitory balance in neural circuits by promoting the expression of genes involved in GABAergic synapse development. It also activates the CNS midline enhancer and regulates drebrin, a cytoskeletal protein essential for dendritic spine morphology. Dysregulation of NPAS4 has been linked to neurodevelopmental and neuropsychiatric disorders, including schizophrenia, autism spectrum disorder, and cognitive impairment. In neurodegenerative disease research, NPAS4 is gaining attention for its neuroprotective roles in response to excitotoxic stress and its potential to modulate synaptic resilience. Its activity-dependent expression profile makes it a promising biomarker and therapeutic target for preserving synaptic integrity in aging and disease.

Neuronal PAS domain-containing protein 4, Neuronal PAS4, Class E basic helix-loop-helix protein 79, HLH-PAS transcription factor NXF, PAS domain-containing protein 10, Limbic-enhanced PAS protein, bHLHe79, PASD10, LE-PAS

A 1:100 dilution of SMC-495 was sufficient for detection of NPAS4 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.