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NPAS4 Antibody, Clone N408/79: RPE

Mouse Anti-Rat NPAS4 Monoclonal IgG1

Product Specifications

Background

NPAS4 (Neuronal PAS Domain Protein 4) is a brain-specific transcription factor that plays a pivotal role in regulating activity-dependent gene expression critical for synaptic plasticity, learning, and memory. As a member of the bHLH-PAS family, NPAS4 is rapidly induced by neuronal activity and orchestrates the formation and maintenance of inhibitory synapses, particularly in excitatory neurons. NPAS4 modulates the excitatory-inhibitory balance in neural circuits by promoting the expression of genes involved in GABAergic synapse development. It also activates the CNS midline enhancer and regulates drebrin, a cytoskeletal protein essential for dendritic spine morphology. Dysregulation of NPAS4 has been linked to neurodevelopmental and neuropsychiatric disorders, including schizophrenia, autism spectrum disorder, and cognitive impairment. In neurodegenerative disease research, NPAS4 is gaining attention for its neuroprotective roles in response to excitotoxic stress and its potential to modulate synaptic resilience. Its activity-dependent expression profile makes it a promising biomarker and therapeutic target for preserving synaptic integrity in aging and disease.

CAS Number

9007-83-4

Specifications

Detects ~90kDa.

Product Name Alternative

Neuronal PAS domain-containing protein 4, Neuronal PAS4, Class E basic helix-loop-helix protein 79, HLH-PAS transcription factor NXF, PAS domain-containing protein 10, Limbic-enhanced PAS protein, bHLHe79, PASD10, LE-PAS

Synonyms

NPAS4 Antibody, Clone N408/79: RPE

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

266734

Swiss Prot

Q8CJH6

Accession Number

NP_705890.1

Cellular Locus

Cytoplasm | Nucleus

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 597-802 (C-terminus) of rat Npas4.

Target

NPAS4

Clonality

Monoclonal

Isotype

IgG1

Clone

N408/79 (Formerly sold as S408-79)

Conjugation

RPE

Tissue Specificity

Highly expressed in the brain, with lower expression found in endocrine tissue.

Type

Monoclonal

Applications

WB | IHC | ICC/IF

Validated Applications

WB,IHC,ICC/IF

Field of Research

Cell Signaling | Epigenetics and Nuclear Signaling | Neuroscience

Purification

Protein G Purified

Limit Of Detection

A 1:100 dilution of SMC-495 was sufficient for detection of NPAS4 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Zhaohui Z., et al. (2014) Exp Ther Med. 7(4): 1045-1049. 2. Coutellier L., et al. (2012) Plos One. 7(9): e46604.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Product Datasheet

https://www.stressmarq.com/wp-content/uploads/2015/05/R-PE-Fluorescent-conjugate.pdf

Product MSDS

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Specificity

Detects ~90kDa.

Background Reference 01

1. Zhaohui Z., et al. (2014) Exp Ther Med. 7 (4) : 1045-1049. 2. Coutellier L., et al. (2012) Plos One. 7 (9) : e46604.

Species

Human | Mouse | Rat

Location

Cytoplasm | Nucleus

Isotype

IgG1

Immunogen Species

Rat

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