Brontictuzumab
Brontictuzumab (OMP 52M51) is a monoclonal antibody (MAb) that inhibits Notch1 signal. Brontictuzumab selectively binds the negative regulatory region of the Notch1. Brontictuzumab inhibits tumor cell proliferation. Brontictuzumab can be used in the research of leukemia and lymphoma[1][2][3].
Product Specifications
CAS Number
1447814-75-6
Product Name Alternative
OMP 52M51; Anti-Human NOTCH1 Recombinant Antibody
UNSPSC
12352203
Target
Notch
Type
Inhibitory Antibodies
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brontictuzumab.html
Purity
95.00
Solubility
10 mM in DMSO
Smiles
[Brontictuzumab]
Molecular Weight
(150 kDa)
References & Citations
[1]Ferrarotto R, et al. A phase I dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors. Ann Oncol. 2018 Jul 1;29 (7) :1561-1568. |[2]Silkenstedt E, et al. Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy. J Exp Clin Cancer Res. 2019 Nov 1;38 (1) :446. |[3]Agnusdei V, et al. Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts. Leukemia. 2014 Feb;28 (2) :278-88.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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