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Neuroligin-4 Antibody, Clone N98/7 : APC

Mouse Anti-Mouse Neuroligin-4 Monoclonal IgG1

Product Specifications

Background

Neuroligin 4 (NLGN4) is a neuronal cell surface protein that contributes to the formation and remodeling of synapses in the central nervous system. As a member of the neuroligin family, NLGN4 binds to presynaptic neurexins, facilitating the development of functional synaptic junctions. NLGN4 is implicated in the specification of inhibitory synapses and is enriched in postsynaptic densities. It interacts with scaffolding proteins such as DLG4 (PSD-95), influencing synaptic stability and receptor clustering. Mutations in NLGN4 have been linked to autism spectrum disorders and intellectual disability, highlighting its role in neurodevelopmental processes. In neurodegenerative disease, synaptic dysfunction is a key early event. Altered NLGN4 expression or function may disrupt inhibitory signaling, contributing to excitotoxicity and network imbalance. Its involvement in synaptic maintenance suggests that NLGN4 may serve as a biomarker for early synaptic pathology and a potential target for therapeutic intervention. Understanding NLGN4’s role in synaptic regulation offers valuable insights into the molecular basis of cognitive decline and neurodegeneration.

Specifications

Detects ~125-130kDa. Does not cross-react with other Neuroligins.

Product Name Alternative

ASPGX2, AUTSX2, HLNX, HNLX, KIAA1260, MGC22376, NLGN, NLGN4, NLGN4X, neuroligin-4 X-linked, neuroligin X, neuroligin 4, X-linked

Synonyms

Neuroligin 4 Antibody, Clone N98/7 : APC

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

100113365

Swiss Prot

B0F2B4

Accession Number

ABS19580

Cellular Locus

Cell Membrane | Cell Junction

Host

Mouse

Species Reactivity

Mouse,Rat

Immunogen

Fusion protein amino acids 782-945 (intracellular C-terminus) of mouse Neuroligin 4. ~45% identity with Neuroligin-1, -2 and -3.

Target

Neuroligin 4

Clonality

Monoclonal

Isotype

IgG1

Clone

N98/7 (Formerly sold as S98-7)

Conjugation

APC

Type

Monoclonal

Applications

WB | IHC | ICC/IF

Validated Applications

IHC,ICC/IF

Field of Research

Neuroscience | Cell Markers | Neuron Markers | Postsynaptic Markers

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-469 was sufficient for detection of Neuroligin 4 in 20 µg of mouse brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Product Datasheet

https://www.stressmarq.com/wp-content/uploads/2015/05/APC-Fluorescent-conjugate.pdf

Product MSDS

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Specificity

Detects ~125-130kDa. Does not cross-react with other Neuroligins.

Species

Mouse | Rat

CAS Number

9007-83-4

Location

Cell Membrane | Cell Junction

Isotype

IgG1

Immunogen Species

Mouse

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