WP1066
WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.
Product Specifications
CAS Number
857064-38-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; JAK; STAT
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/WP1066.html
Purity
99.77
Solubility
DMSO : ≥ 44 mg/mL|Ethanol : 16.67 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C1=CC=CC=C1)C)/C(C#N)=C/C2=NC(Br)=CC=C2
Molecular Formula
C17H14BrN3O
Molecular Weight
356.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Verstovsek S, et al. WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin Cancer Res, 2008, (3), 788-796.|[2]Hatiboglu MA, et al. The tumor microenvironment expression of p-STAT3 influences the efficacy of WP1066 in murine melanoma models. Int J Cancer, 2012, 131 (1), 8-17|[3]Ferrajoli A, et al. WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells. Cancer Res, 2007, 67 (23), 11291-11299.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
JAK2; STAT3
Available Sizes
Frequently Asked Questions
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