SKI V

SKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with an IC50 of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC50 of 6 μM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) . SKI V induces apoptosis and has antitumor activity[1][2].

Product Specifications

CAS Number

[24418-86-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; PI3K; SphK

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ski-v.html

Purity

98.95

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1/C(OC2=CC=CC=C12)=C/C3=CC=C(O)C(O)=C3

Molecular Formula

C15H10O4

Molecular Weight

254.24

Precautions

H302, H315, H319

References & Citations

[1]French KJ, et al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63 (18) :5962-9.|[2]French KJ, et al. Antitumor activity of sphingosine kinase inhibitors. J Pharmacol Exp Ther. 2006 Aug;318 (2) :596-603.