Protocadherin Gamma Antibody, Clone N159/5: HRP

Mouse Anti-Mouse Protocadherin Gamma (pan) Monoclonal IgG1

Product Specifications

Background

Protocadherin Gamma is part of a large gene cluster on chromosome 5, organized in an immunoglobulin-like tandem array. This cluster includes 22 genes divided into three subfamilies (A, B, and C), each encoding neural cadherin-like cell adhesion proteins. Each gene contains a variable region exon encoding six extracellular cadherin domains and a transmembrane region, followed by three constant region exons encoding a shared cytoplasmic domain. This structure enables diverse cell-cell recognition and adhesion mechanisms in the brain. Protocadherin Gamma proteins are critical for establishing and maintaining specific neuronal connections. Their alternative splicing and combinatorial expression contribute to synaptic specificity and neural circuit formation. Dysregulation of these proteins may impair synaptic connectivity and has been implicated in neurodevelopmental and neurodegenerative disorders.

CAS Number

9007-83-4

Specifications

Detects ~100kDa. Cross-reacts with all Gamma-protocadherin-A, -B and -C proteins.

Product Name Alternative

PCDH gamma A, PCDH-gamma-A, PCDHGA, Protocadherin gamma A, Protocadherin gamma subfamily A, Gamma Protocadherin A (pan), Pan-Gamma-Protocadherin-A, Pan Gamma Protocadherin A, PCDHGA1, PCDHGA4, PCDHGC4, Protocadherin gamma-A1, Protocadherin gamma-A4, Protocadherin gamma-C4

Synonyms

Protocadherin Gamma Antibody, Clone N159/5: HRP

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

93709

Swiss Prot

Q91XZ0

Accession Number

NP_291062.1

Cellular Locus

Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein corresponding to amino acids 808-931 (C-terminal cytoplasmic constant domain) of mouse Protocadherin-gamma-A1 that is shared by all 22 Gamma-protocadherins (A subfamily amino acids ~807-930, B subfamily amino acids ~789-912 and C subfamily amino acids ~818-941) . 99% identity with human (123/124 amino acids) .

Target

Protocadherin Gamma

Clonality

Monoclonal

Isotype

IgG1

Clone

N159/5 (Formerly sold as S159-5)

Conjugation

HRP

Type

Monoclonal

Applications

WB | IHC | ICC/IF

Validated Applications

WB,IHC,ELISA

Field of Research

Neuroscience | Cell Markers | Neuron Markers | Membrane Markers

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-454 was sufficient for detection of Protocadherin gamma (pan) in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.