FR 180204

FR 180204 is an ATP-competitive and selective ERK inhibitor. FR 180204 inhibits ERK1 and ERK2 with IC50s of 0.51 μM (Ki=0.31 μM) and 0.33 μM (Ki=0.14 μM), respectively[1].

Product Specifications

CAS Number

[865362-74-9]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Dengue Virus; ERK; Flavivirus

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/FR-180204.html

Purity

99.91

Solubility

DMSO : ≥ 50 mg/mL

Smiles

NC1=NNC2=NN=C(C3=C4C=CC=CN4N=C3C5=CC=CC=C5)C=C21

Molecular Formula

C18H13N7

Molecular Weight

327.34

Precautions

H302

References & Citations

[1]Ohori M, et al. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochem Biophys Res Commun. 2005 Oct 14;336 (1) :357-63.|[2]Ohori M, et al. FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jan;374 (4) :311-6.|[3]Honda M, et al. Mesothelioma cell proliferation through autocrine activation of PDGF-ββ receptor. Cell Physiol Biochem. 2012;29 (5-6) :667-74|[4]Sreekanth GP, et al. Role of ERK1/2 signaling in dengue virus-induced liver injury. Virus Res. 2014 Aug 8;188:15-26