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Protocadherin Gamma Antibody, Clone N159/5: Biotin

Mouse Anti-Mouse Protocadherin Gamma (pan) Monoclonal IgG1

Product Specifications

Background

Protocadherin Gamma is part of a large gene cluster on chromosome 5, organized in an immunoglobulin-like tandem array. This cluster includes 22 genes divided into three subfamilies (A, B, and C), each encoding neural cadherin-like cell adhesion proteins. Each gene contains a variable region exon encoding six extracellular cadherin domains and a transmembrane region, followed by three constant region exons encoding a shared cytoplasmic domain. This structure enables diverse cell-cell recognition and adhesion mechanisms in the brain. Protocadherin Gamma proteins are critical for establishing and maintaining specific neuronal connections. Their alternative splicing and combinatorial expression contribute to synaptic specificity and neural circuit formation. Dysregulation of these proteins may impair synaptic connectivity and has been implicated in neurodevelopmental and neurodegenerative disorders.

Specifications

Detects ~100kDa. Cross-reacts with all Gamma-protocadherin-A, -B and -C proteins.

Product Name Alternative

PCDH gamma A, PCDH-gamma-A, PCDHGA, Protocadherin gamma A, Protocadherin gamma subfamily A, Gamma Protocadherin A (pan), Pan-Gamma-Protocadherin-A, Pan Gamma Protocadherin A, PCDHGA1, PCDHGA4, PCDHGC4, Protocadherin gamma-A1, Protocadherin gamma-A4, Protocadherin gamma-C4

Synonyms

Protocadherin Gamma Antibody, Clone N159/5: Biotin

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

93709

Swiss Prot

Q91XZ0

Accession Number

NP_291062.1

Cellular Locus

Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein corresponding to amino acids 808-931 (C-terminal cytoplasmic constant domain) of mouse Protocadherin-gamma-A1 that is shared by all 22 Gamma-protocadherins (A subfamily amino acids ~807-930, B subfamily amino acids ~789-912 and C subfamily amino acids ~818-941) . 99% identity with human (123/124 amino acids) .

Target

Protocadherin Gamma

Clonality

Monoclonal

Isotype

IgG1

Clone

N159/5 (Formerly sold as S159-5)

Conjugation

Biotin

Type

Monoclonal

Applications

WB | IHC | ICC/IF

Validated Applications

WB,IHC,ICC/IF |ELISA

Field of Research

Neuroscience | Cell Markers | Neuron Markers | Membrane Markers

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-454 was sufficient for detection of Protocadherin gamma (pan) in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

136.36mM Ethanolamine, 133.23 mM Chlorides, 9.55mM Phosphates, 9.55mM Sodium Bicarbonate

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Product Datasheet

https://www.stressmarq.com/wp-content/uploads/Biotin-Protein-Conjugate.pdf

Product MSDS

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Specificity

Detects ~100kDa. Cross-reacts with all Gamma-protocadherin-A, -B and -C proteins.

Species

Human | Mouse | Rat

CAS Number

9007-83-4

Location

Cell Membrane

Isotype

IgG1

Immunogen Species

Mouse

Curated Selection

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