L-NMMA (acetate)

L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 μM, respectively.

Product Specifications

CAS Number

[53308-83-1]

Product Name Alternative

Tilarginine (acetate) ; Methylarginine (acetate)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/L-NMMA_acetate.html

Purity

99.0

Solubility

H2O : ≥ 50 mg/mL

Smiles

N[C@@H](CCCNC(NC)=N)C(O)=O.O=C(C)O

Molecular Formula

C9H20N4O4

Molecular Weight

248.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Frey C, et al. L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem. 1994 Oct 21;269 (42) :26083-91.|[2]Maggi CA, et al. Effect of NG-monomethyl L-arginine (L-NMMA) and NG-nitro L-arginine (L-NOARG) on non-adrenergic non-cholinergic relaxation in the circular muscle of the human ileum. Br J Pharmacol. 1991 Aug;103 (4) :1970-2.|[3]Nakamura T, et al. Effect of NG-monomethyl-L-arginine on arcade arterioles of rat spinotrapezius muscles. Am J Physiol. 1991 Jul;261 (1 Pt 2) :H46-52.