FHF2A (FGF13) Antibody, Clone N235/22

Mouse Anti-Human FHF2A (FGF13) Monoclonal IgG2b

Product Specifications

Background

Fibroblast growth factor 13 (FGF13) is a non-secreted member of the FGF family that functions intracellularly to regulate neuronal excitability, microtubule stabilization, and axonal development. Unlike classical FGFs, FGF13 does not act through FGF receptors but instead modulates ion channel activity and cytoskeletal dynamics. In the central nervous system, FGF13 is essential for proper neuronal migration and synaptic function. Mutations or altered expression of FGF13 have been linked to epilepsy, intellectual disability, and neurodevelopmental disorders. Recent studies suggest that FGF13 may also play a role in neurodegenerative diseases by influencing axonal transport and mitochondrial dynamics—processes disrupted in Alzheimer’s and ALS. FGF13’s unique intracellular functions make it a compelling candidate for targeted therapies aimed at preserving neuronal integrity and function in neurodegenerative conditions.

CAS Number

9007-83-4

Specifications

Detects ~30kDa. Does not cross-react with FGF13B/FHF2B. Cross reacts with FGF12A/FHF1A and FGF14A/FHF4A.

Product Name Alternative

FGF-13, FHF-2, FGF13, FHF2, Fibroblast growth factor homologous factor 2A, Fibroblast growth factor 13A, FGF13A

Synonyms

FGFA/FHFA (pan) Antibody, Clone N235/22

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

2258

Swiss Prot

Q92913

Accession Number

AAH34340

Cellular Locus

Cell Projection | Growth Cone | Dendrite | Nucleus | Cytoplasm

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide amino acids 2-18 (AAAIASSLIRQKRQARE) of human FHF2A. 100% identical to rat, 94% identical to mouse. >80% identity with FGF12A/FHF1A, FGF14A/FHF4A and FGF11A/FHF3A.

Target

FGF13

Clonality

Monoclonal

Isotype

IgG2b

Clone

N235/22

Conjugation

Unconjugated

Type

Monoclonal

Applications

WB | IHC | ICC/IF

Validated Applications

WB,IHC,ICC/IF

Field of Research

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-448 was sufficient for detection of FHF2A (FGF13) in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000) ; optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.1% sodium azide

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Gecz, J., et al. (1999) Hum. Genet. 104: 56-63. 2. Smallwood, P. M., et al. (1996) Proc. Nat. Acad. Sci. 93: 9850-9857.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects ~30kDa. Does not cross-react with FGF13B/FHF2B. Cross reacts with FGF12A/FHF1A and FGF14A/FHF4A.

Background Reference 01

1. Gecz, J., et al. (1999) Hum. Genet. 104: 56-63. 2. Smallwood, P. M., et al. (1996) Proc. Nat. Acad. Sci. 93: 9850-9857.

Species

Human | Mouse | Rat

Location

Cell Projection | Growth Cone | Dendrite | Nucleus | Cytoplasm

Isotype

IgG2b

Immunogen Species

Human

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