LRRK2 Antibody, Clone N231B/34

Mouse Anti-Human LRRK2 (Dardarin) Monoclonal IgG2a

Product Specifications

Background

LRRK2 (Leucine-Rich Repeat Kinase 2) is a large multidomain protein with kinase and GTPase activity, implicated in the pathogenesis of Parkinson’s disease (PD) and other neurodegenerative disorders. Mutations in LRRK2, such as G2019S, are among the most common genetic causes of familial and sporadic PD. LRRK2 regulates vesicle trafficking, autophagy, cytoskeletal dynamics, and immune responses. Its dysregulation leads to mitochondrial dysfunction, impaired lysosomal degradation, and neuroinflammation. LRRK2 is expressed in neurons and glial cells, and its activity is modulated by cellular stress and inflammatory signals. As a central node in neurodegenerative signaling networks, LRRK2 is a high-priority target for disease-modifying therapies in Parkinson’s and related disorders.

CAS Number

9007-83-4

Specifications

Detects >200kDa.

Product Name Alternative

LRRK2, Leucine-rich repeat kinase 2, Leucine-rich repeat serine/threonine-protein kinase 2, RIP7, RIPK7, PARK8, Dardarin, ROCO 2, Augmented in rheumatoid arthritis 17

Synonyms

LRRK2/Dardarin Antibody, Clone N231B/34

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

120892

Swiss Prot

Q5S007

Accession Number

NP_940980

Cellular Locus

Host

Mouse

Species Reactivity

Human,Rat

Immunogen

Fusion protein amino acids 841-960 of human LRRK2. 81% identical in mouse, 80% identical in rat. <30% identity with LRRK1.

Target

LRRK2

Clonality

Monoclonal

Isotype

IgG2a

Clone

N231B/34 (Formerly sold as S231B-34)

Conjugation

Unconjugated

Type

Monoclonal

Applications

WB | ICC/IF | IHC

Validated Applications

WB,ICC/IF,IHC

Field of Research

Purification

Protein G Purified

Limit Of Detection

10 µg/ml of SMC-445 was sufficient for detection of LRRK2/Dardarin in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.