Alpha-2C Adrenergic Antibody, Clone N330A/80

The Alpha-2C Adrenergic Receptor (ADRA2C) is a G protein-coupled receptor that plays a critical role in modulating neurotransmitter release from central adrenergic neurons and sympathetic nerves, particularly in the brain and heart. Widely expressed in the central nervous system, ADRA2C is involved in regulating synaptic transmission, stress responses, and higher-order cognitive and behavioral functions. Two isoforms of ADRA2C are produced via alternative splicing, with predominant expression in brain regions implicated in memory, emotion, and executive function. Beyond the CNS, ADRA2C is also found in peripheral tissues including the heart, kidney, blood, and corpus cavernosum, suggesting a broader physiological role. In the context of neurodegenerative disease, dysregulation of ADRA2C signaling has been linked to impaired noradrenergic tone, altered synaptic plasticity, and neuroinflammation—key features observed in disorders such as Alzheimer’s disease, Parkinson’s disease, and schizophrenia. Its involvement in modulating cognitive resilience and behavioral regulation positions ADRA2C as a promising biomarker and therapeutic target in neuropsychiatric and neurodegenerative research. Ongoing studies are exploring ADRA2C agonists and antagonists for their potential to restore neurotransmitter balance, enhance cognitive function, and mitigate neurodegenerative progression

Alpha-2C Adrenergic Receptor, Alpha-2C Adrenoceptor, Alpha-2C Adrenoreceptor, ADRA2C, ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR, Alpha2-AR-C4, Alpha2-C4, Adrenoceptor Alpha 2C, Adrenergic receptor alpha 2C

1 µg/ml of SMC-435 was sufficient for detection of Alpha2C Adrenergic Receptor in 20 µg of COS cells transiently transfected with HA-tagged Alpha- lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.