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GluN2A (NR2A, NMDA Receptor 2A) Antibody, Clone N327/95: Biotin

Mouse Anti-Rat GluN2A Monoclonal IgG2A

Product Specifications

Background

NR2A (GRIN2A) is a subunit of the N-methyl-D-aspartate (NMDA) receptor, a glutamate-gated ion channel essential for synaptic plasticity, learning, and memory. NR2A-containing NMDA receptors are predominantly expressed in the postnatal and adult brain, where they contribute to fast synaptic transmission and long-term potentiation (LTP) . NR2A plays a critical role in calcium influx and downstream signaling cascades that regulate gene expression, synaptic remodeling, and neuronal survival. Alterations in NR2A expression or function have been implicated in neurodegenerative diseases such as Alzheimer’s disease, where NMDA receptor dysregulation contributes to excitotoxicity and synaptic loss. In addition to its role in cognition, NR2A is involved in neurodevelopment and the fine-tuning of excitatory synaptic strength. Its interaction with scaffolding proteins and signaling molecules positions it as a key modulator of synaptic architecture and plasticity. Targeting NR2A-containing NMDA receptors offers a potential therapeutic strategy for modulating glutamatergic signaling in neurodegenerative and neuropsychiatric disorders.

Specifications

Detects ~170kDa. Does not react with NR2B.

Product Name Alternative

NMDA 2A, NMDAR2A, NMDAR 2A, NMDA Receptor 2A, Glutamate Receptor, GRIN2A, Glutamate [NMDA] Receptor subunit epsilon-1, Glutamate receptor ionotropic N methyl D aspartate 2A, HNR2A, N methyl D aspartate receptor channel, subunit epsilon 1, N Methyl D Aspartate Receptor Subtype 2A, N methyl D aspartate receptor subunit 2A, NMDA receptor subtype 2A, NMDA Receptor Type 2A, OTTHUMP00000160135, OTTHUMP00000174531

Synonyms

GluN2A/NR2A Antibody, Clone N327/95: Biotin

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

24409

Swiss Prot

Q00959

Accession Number

NP_036705.3

Cellular Locus

Cell Membrane | Cell Junction

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 75-325 (extracellular N-terminus) of rat GluN2A

Target

NMDAR2A NMDA

Clonality

Monoclonal

Isotype

IgG2A

Clone

N327/95

Conjugation

Biotin

Type

Monoclonal

Applications

WB | IHC | ICC/IF

Validated Applications

WB,IHC,ICC/IF |ELISA

Field of Research

Neuroscience | Neurotransmitter Receptors | Glutamate Receptors | NMDA Receptors | Cell Signaling

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-429 was sufficient for detection o GluN2A in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

136.36mM Ethanolamine, 133.23 mM Chlorides, 9.55mM Phosphates, 9.55mM Sodium Bicarbonate

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Teng H.J., et al. (2010) PLoS ONE. 5: e13342.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Product Datasheet

https://www.stressmarq.com/wp-content/uploads/Biotin-Protein-Conjugate.pdf

Product MSDS

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Specificity

Detects ~170kDa. Does not react with NR2B.

Background Reference 01

1. Teng H.J., et al. (2010) PLoS ONE. 5: e13342.

Species

Human | Mouse | Rat

CAS Number

9007-83-4

Location

Cell Membrane | Cell Junction

Isotype

IgG2A

Immunogen Species

Rat

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