Brevican Antibody

Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE.

BCAN Antibody, BEHAB Antibody, CSPG7 Antibody, Brain enriched hyaluronan binding protein Antibody, Brevican core protein Antibody, Brevican core protein isoform 1 Antibody, Brevican core protein isoform 2 Antibody, Brevican proteoglycan Antibody, Chondroitin sulfate proteoglycan 7 Antibody, Chondroitin sulfate proteoglycan BEHAB Antibody, MGC13038 Antibody

1 µg/ml of SMC-428 was sufficient for detection of Brevican in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

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