ASIC1 Antibody, Clone N271/44: FITC

Acid-sensing ion channel 1 (ASIC1), also known as ASIC1a, ACCN2, and BNAC2, is a proton-gated cation channel highly expressed in the central nervous system. It plays a critical role in detecting extracellular pH changes and mediating neuronal excitability in response to acidosis. ASIC1 is encoded as a 4.3-kb transcript and is prominently localized in the rat brain, particularly in the olfactory bulb, cerebral cortex, hippocampus, habenula, basolateral amygdala, and cerebellum. Functionally, ASIC1 contributes to synaptic plasticity, learning, and memory, and is involved in the modulation of fear and anxiety-related behaviors. Its activation by protons leads to sodium influx, influencing neuronal firing and excitotoxicity under pathological conditions. In the context of neurodegenerative disease, ASIC1 has gained attention for its role in ischemic brain injury, traumatic brain injury, and chronic neuroinflammation. ASIC1a, the predominant isoform in neurons, is permeable to calcium and has been implicated in acidosis-induced neuronal death—a common feature in stroke and neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Given its dual role in physiological signaling and pathological damage, ASIC1 is emerging as a promising therapeutic target. Inhibiting ASIC1 activity may offer neuroprotection by reducing calcium overload and excitotoxicity in vulnerable brain regions. Understanding the spatial expression and functional dynamics of ASIC1 is essential for advancing therapeutic strategies in neurodegenerative disease research.

ASIC1, ACCN2, BNAC2, Acid-sensing ion channel 1, Acid-sensing (proton-gated) ion channel, Amiloride-sensitive cation channel 2 neuronal, Brain sodium channel 2

1 µg/ml of SMC-427 was sufficient for detection of ASIC1 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

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1. Garcia-Anoveros J., Derfler B., Neville-Golden J., Hyman B.T. and Corey D.P. (1997) Proc. Natl. Acad. Sci. USA 94: 1459-1464. 2. Waldmann R., Champigny G., Bassilana F., Heurteaux C. and Lazdunski M. (1997) Nature. 386: 173-177. 3. Grunder S., Geisler H.S., Rainier S. and Fink J.K. (2001) Eur. J. Hum. Genet. 9:672-676. 4. Chen C.C., Zimmer A., Sun W.H., Hall J., Brownstein M.J. and Zimmer A. (2002) Proc. Natl. Acad. Sci. USA 99: 8992-8997. 5. Wemmie J.A., et al. (2004) Proc. Natl. Acad. Sci. USA 101: 3621-3626 .