Stargazin Antibody, Clone N245/36

Mouse Anti-Rat TARP Gamma2/4/8 (Stargazin) Monoclonal IgG2A

Product Specifications

Background

Stargazin, also known as CACNG2, is a transmembrane protein originally classified as a subunit of voltage-gated calcium channels (VGCCs) . While it was first thought to stabilize VGCCs in an inactivated state, Stargazin is now recognized for its pivotal role in regulating AMPA-type glutamate receptors (AMPARs) at excitatory synapses. In the central nervous system, Stargazin anchors AMPARs to the postsynaptic membrane and modulates their trafficking, gating, and synaptic localization. This regulation is essential for synaptic plasticity, learning, and memory—processes that are often disrupted in neurodegenerative diseases. Dysfunction of Stargazin or its interaction with AMPARs has been implicated in several neurological disorders, including epilepsy, intellectual disability, and Alzheimer’s disease. Altered Stargazin expression or phosphorylation can impair synaptic strength and contribute to excitotoxicity, a key driver of neuronal death in neurodegeneration. Moreover, Stargazin’s role in maintaining calcium homeostasis and modulating excitatory neurotransmission positions it as a potential therapeutic target for restoring synaptic balance in neurodegenerative conditions. As a critical link between ion channel regulation and synaptic signaling, Stargazin continues to gain attention in neuroscience for its contributions to both normal brain function and disease pathology.

CAS Number

9007-83-4

Specifications

Detects ~35-55kDa. Does not cross-react with TARPGamma3.

Product Name Alternative

CACNG2, Calcium channel voltage dependent gamma subunit 2, CaV gamma 2, Ipr328, MGC123981, MGC138502, MGC138504, Voltage-dependent calcium channel gamma-2 subunit, Neuronal voltage-gated calcium channel gamma-2 subunit, Stargazin, Stg, Stargazer, TARP, TARP gamma-2, Transmembrane AMPAR regulatory protein gamma-2, AW060990, B230105C07Rik, B930041E13Rik, Wag, Waggler

Synonyms

TARP Gamma2/4/8 (Stargazin) Antibody, Clone N245/36

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

84347

Swiss Prot

Q71RJ2

Accession Number

NP_445803.1

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2

Target

Stargazin

Clonality

Monoclonal

Isotype

IgG2A

Clone

N245/36 (Formerly sold as S245-36)

Conjugation

Unconjugated

Type

Monoclonal

Applications

WB | ICC/IF

Validated Applications

WB,ICC/IF

Field of Research

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-422 was sufficient for detection of TARP Gamma2/4/8 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Gill M.B., et al. (2011) J Neurosci. 31(18): 6928-6938. 2. Yu L. (2011) Neuroscience. 178: 13-20. 3. Steinmetz C.C., Turrigiano G.G. (2010) J Neurosci. 30: 14685-14690. 4. Kato. A.S. et al. (2007) J Neurosci. 27: 4969-4977. 5. Letts V.A., et al. (1998) Nat Genet. 19: 340-34

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects ~35-55kDa. Does not cross-react with TARPGamma3.

Background Reference 01

1. Gill M.B., et al. (2011) J Neurosci. 31 (18) : 6928-6938. 2. Yu L. (2011) Neuroscience. 178: 13-20. 3. Steinmetz C.C., Turrigiano G.G. (2010) J Neurosci. 30: 14685-14690. 4. Kato. A.S. et al. (2007) J Neurosci. 27: 4969-4977. 5. Letts V.A., et al. (1998) Nat Genet. 19: 340-34