LRP4 (Extracellular) Antibody, Clone N207/27: Biotin

Mouse Anti-Mouse LRP4 (Extracellular) Monoclonal IgG2A

Product Specifications

Background

LRP4 (Low-Density Lipoprotein Receptor-Related Protein 4) is a transmembrane receptor essential for neuromuscular junction formation and synaptic signaling. It acts as a co-receptor for agrin and MuSK, facilitating synapse development and maintenance. In the central nervous system, LRP4 influences astrocyte-neuron communication and synaptic plasticity. Mutations or autoantibodies targeting LRP4 are linked to myasthenia gravis and may contribute to cognitive dysfunction. Emerging evidence suggests LRP4 plays a role in neurodegenerative diseases by modulating synaptic integrity and glial function. Its involvement in both peripheral and central synaptic regulation positions LRP4 as a promising target for therapeutic intervention in neuromuscular and neurodegenerative disorders.

CAS Number

9007-83-4

Specifications

Detects the extracellular domain of LRP4 ~215kDa. Degradation product can be seen at ~150kDa.

Product Name Alternative

LRP4, LRP-4, LRP10, MEGF7, Low density lipoprotein receptor related protein 4, Multiple epidermal growth factor like domains 7, LDLR dan, LDLR, KIAA0816, Corin

Synonyms

LRP4 Antibody, Clone N207/27: Biotin

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

83469

Swiss Prot

Q8VI56

Accession Number

NP_766256.3

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 26- 350 (extracellular N-terminus) of mouse LTP4

Target

LRP4

Clonality

Monoclonal

Isotype

IgG2A

Clone

N207/27 (Formerly sold as S207-27)

Conjugation

Biotin

Type

Recombinant Monoclonal

Applications

WB | ICC/IF

Validated Applications

WB,IHC,ICC/IF |ELISA

Field of Research

Neuroscience | Cell Markers | Neuron Markers | Membrane Markers | Cell Signaling

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-418 was sufficient for detection of LRP4 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

136.36mM Ethanolamine, 133.23 mM Chlorides, 9.55mM Phosphates, 9.55mM Sodium Bicarbonate

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 1353–92.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Specificity

Detects the extracellular domain of LRP4 ~215kDa. Degradation product can be seen at ~150kDa.

Background Reference 01

1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3) : 1353–92.

Species

Human | Mouse | Rat

Location

Membrane

Isotype

IgG2A

Immunogen Species

Mouse

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