LRP4 (Extracellular) Antibody, Clone N207/27

Mouse Anti-Mouse LRP4 (Extracellular) Monoclonal IgG2A

Product Specifications

Background

LRP4 (Low-Density Lipoprotein Receptor-Related Protein 4) is a transmembrane receptor essential for neuromuscular junction formation and synaptic signaling. It acts as a co-receptor for agrin and MuSK, facilitating synapse development and maintenance. In the central nervous system, LRP4 influences astrocyte-neuron communication and synaptic plasticity. Mutations or autoantibodies targeting LRP4 are linked to myasthenia gravis and may contribute to cognitive dysfunction. Emerging evidence suggests LRP4 plays a role in neurodegenerative diseases by modulating synaptic integrity and glial function. Its involvement in both peripheral and central synaptic regulation positions LRP4 as a promising target for therapeutic intervention in neuromuscular and neurodegenerative disorders.

CAS Number

9007-83-4

Specifications

Detects the extracellular domain of LRP4 ~215kDa. Degradation product can be seen at ~150kDa.

Product Name Alternative

LRP4, LRP-4, LRP10, MEGF7, Low density lipoprotein receptor related protein 4, Multiple epidermal growth factor like domains 7, LDLR dan, LDLR, KIAA0816, Corin

Synonyms

LRP4 Antibody, Clone N207/27

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

83469

Swiss Prot

Q8VI56

Accession Number

NP_766256.3

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 26- 350 (extracellular N-terminus) of mouse LTP4

Target

LRP4

Clonality

Monoclonal

Isotype

IgG2A

Clone

N207/27 (Formerly sold as S207-27)

Conjugation

Unconjugated

Type

Recombinant Monoclonal

Applications

WB | ICC/IF

Validated Applications

WB,ICC/IF

Field of Research

Neuroscience | Cell Markers | Neuron Markers | Membrane Markers | Cell Signaling

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-418 was sufficient for detection of LRP4 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 1353–92.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects the extracellular domain of LRP4 ~215kDa. Degradation product can be seen at ~150kDa.

Background Reference 01

1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3) : 1353–92.

Species

Human | Mouse | Rat

Location

Membrane

Isotype

IgG2A

Immunogen Species

Mouse

Curated Selection

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