DC-Chol (hydrochloride)

DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity[1][2][3].

Product Specifications

CAS Number

[166023-21-8]

Product Name Alternative

DC-Cholesterol (hydrochloride)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β; IFNAR; Interleukin Related; Liposome

Type

Oligonucleotides

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dc-chol-hydrochloride.html

Purity

99.91

Solubility

Ethanol : 12.5 mg/mL (ultrasonic)

Smiles

CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(NCCN(C)C)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C.[H]Cl

Molecular Formula

C32H57ClN2O2

Molecular Weight

537.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Esmail A Elbassal, et al. Effects of Charged Cholesterol Derivatives on Aβ40 Amyloid Formation. J Phys Chem B. 2016 Jan 14;120 (1) :59-68.|[2]Richard Lantz, et al. Effects of disulfide bond and cholesterol derivatives on human calcitonin amyloid formation. Biopolymers. 2020 May;111 (5) :e23343.|[3]Brunel F, et al. Cationic lipid DC-Chol induces an improved and balanced immunity able to overcome the unresponsiveness to the hepatitis B vaccine. Vaccine. 1999 Apr 23;17 (17) :2192-203.