GluN1 (NR1, NMDA Receptor 1) Antibody, Clone N308/48

The N-methyl-D-aspartate receptor (NMDA receptor or NMDAR) is a glutamate-gated ion channel essential for synaptic plasticity, learning, and memory. Central to its function is the GluN1 subunit, encoded by the GRIN1 gene, which is an obligatory component of all functional NMDAR complexes. Each receptor is a heterotetramer typically composed of two GluN1 subunits and two regionally expressed GluN2 (A-D) subunits. The GluN1 subunit not only anchors the receptor’s core structure but also modulates its biophysical and pharmacological properties through alternative splicing, generating multiple isoforms with distinct functional profiles. GluN1’s ubiquitous expression and essential role in receptor assembly make it a focal point in neuroscience and neurodegenerative disease research. Dysregulation of GluN1 expression or splicing has been implicated in a range of neurological disorders, including Alzheimer’s disease, Huntington’s disease, and schizophrenia. Additionally, GluN3 subunits (A and B), which can co-assemble with GluN1, exert inhibitory effects on receptor activity, further influencing disease-relevant signaling pathways. Understanding GluN1’s molecular diversity and regulatory mechanisms is critical for developing targeted therapies aimed at restoring NMDAR function in neurodegenerative and neuropsychiatric conditions.

GRIN1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor ionotropic N methyl D aspartate 1, MRD8, Methyl-D-aspartate receptor subunit zeta-1, N methyl D aspartate receptor, N methyl D aspartate receptor channel subunit zeta 1, N methyl D aspartate receptor subunit NR1, NMD-R1, NMDA 1, NMDA R1, NMDA Receptor 1, NMDA1, NMDAR, NMDAR1, NMDZ1_HUMAN, NR1

1 µg/ml of SMC-410 was sufficient for detection of NR1 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

1. Li F., and Tsien J.Z. (2009) New England J. Medicine. 361: 302-303. 2. Garcia-Gallo M., Renart J., Diaz-Guerra M. (2001) Biochem J. 356: 539-547. 3. Atlason P.T., Garside M.L., Meddows E., Whiting P., McIllhinney R.A.J. (2007) J Biol Chem. 282(35): 25299-25307.

1. Li F., and Tsien J.Z. (2009) New England J. Medicine. 361: 302-303. 2. Garcia-Gallo M., Renart J., Diaz-Guerra M. (2001) Biochem J. 356: 539-547. 3. Atlason P.T., Garside M.L., Meddows E., Whiting P., McIllhinney R.A.J. (2007) J Biol Chem. 282 (35) : 25299-25307.