MGluR1/5 Antibody, Clone N75/33

Mouse Anti-Rat mGluR1/5 Monoclonal IgG1

Product Specifications

Background

Metabotropic glutamate receptor 5 (mGluR5) is a G-protein-coupled receptor that modulates excitatory neurotransmission and synaptic plasticity in the central nervous system. It plays a critical role in learning, memory, and neurodevelopment. Dysregulation of mGluR5 signaling has been implicated in a range of neurodegenerative and neuropsychiatric disorders, including Alzheimer’s disease, Huntington’s disease, and fragile X syndrome. Overactivation of mGluR5 can lead to excitotoxicity, neuroinflammation, and synaptic dysfunction. Conversely, pharmacological inhibition of mGluR5 has shown neuroprotective effects in preclinical models by reducing amyloid-beta accumulation, restoring synaptic function, and attenuating cognitive deficits. As a modulator of glutamatergic signaling, mGluR5 represents a promising therapeutic target for restoring neural circuit balance and preventing neurodegenerative progression. Ongoing clinical trials are evaluating mGluR5 antagonists for their efficacy in treating cognitive and behavioral symptoms associated with neurodegeneration.

CAS Number

9007-83-4

Specifications

Detects ~130kDa (both mGluR1 and mGluR5).

Product Name Alternative

MGluR5, mGlu5, GRM5, GPRC1E, Metabotropic glutamate receptor 5, Metabotropic glutamate receptor 5 variant F, Metabotropic glutamate receptor 5 variant G, Metabotropic glutamate receptor 5 variant H, Glutamate receptor metabotropic 5, mGluR5a, mGluR5b, mGluR, Glutamate receptor metabotropic 1, mGlu1, mGluR1, GRM1, GRM 1, GRM1A, GRM1 alpha, GRM1_HUMAN, GPRC1A, Metabotropic glutamate receptor 1, mGluR1 alpha

Synonyms

mGluR1/5 Antibody, Clone N75/33

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

24418

Swiss Prot

P31424

Accession Number

NP_058708.1

Cellular Locus

Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b

Target

mGluR5

Clonality

Monoclonal

Isotype

IgG1

Clone

N75/33 (Formerly sold as S75-33)

Conjugation

Unconjugated

Type

Monoclonal

Applications

WB | IHC | ICC/IF | IP

Validated Applications

WB,IHC,ICC/IF,IP

Field of Research

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-407 was sufficient for detection of mGluR1/5 glutamate receptor in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Mayer M.L. (2005) Current Opinion in Neurobio. 15(3): 282-288. 2. Keinane K., et al. (1990) Science. 249: 556-560.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects ~130kDa (both mGluR1 and mGluR5) .

Background Reference 01

1. Mayer M.L. (2005) Current Opinion in Neurobio. 15 (3) : 282-288. 2. Keinane K., et al. (1990) Science. 249: 556-560.

Species

Human | Mouse | Rat

Location

Cell Membrane

Isotype

IgG1

Immunogen Species

Rat

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