SNAT1 Antibody, Clone N104/32

Mouse Anti-Rat SNAT1 Monoclonal IgG1

Product Specifications

Background

SNAT1, encoded by the SLC38A1 gene, is a sodium-coupled neutral amino acid transporter primarily responsible for glutamine uptake in neurons. As a key component of System A transporters, SNAT1 supports neurotransmitter cycling, energy metabolism, and nitrogen balance in the central nervous system. Highly expressed in specific neuronal populations—but notably absent in astrocytes—SNAT1 facilitates the intracellular accumulation of glutamine, a precursor for glutamate and GABA synthesis. This function is essential for maintaining excitatory and inhibitory neurotransmission, particularly in metabolically active brain regions. Disruption of SNAT1 expression or function has been linked to altered glutamate homeostasis, excitotoxicity, and oxidative stress—hallmarks of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Its role in retinal glutamate generation also suggests broader implications in neuro-ophthalmic disorders. As a neuron-specific transporter with critical roles in synaptic metabolism, SNAT1 represents a compelling target for therapeutic modulation and biomarker discovery in neurodegenerative disease research.

CAS Number

9007-83-4

Specifications

Detects ~50kDa.

Product Name Alternative

SNAT1, SLC38A1, amino acids transporter A1, ATA1, NAT2, sodium coupled neutral amino acids transporter 1, Amino acid transporter system A1, N-system amino acid transporter 2, S38A1, SAT1, SNAT 1, Solute carrier family 38 member 1, System A amino acid transporter 1, System N amino acid transporter 1

Synonyms

SNAT1 Antibody, Clone N104/32

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

170567

Swiss Prot

Q9JM15

Accession Number

NP_620187.1

Cellular Locus

Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 1- 63 of rat SNAT1

Target

SLC38A1

Clonality

Monoclonal

Isotype

IgG1

Clone

N104/32 (Formerly sold as S104-32)

Conjugation

Unconjugated

Type

Monoclonal

Applications

WB | IHC | ICC/IF | FCM

Validated Applications

WB,IHC,ICC/IF,FCM

Field of Research

Neuroscience | Pumps/Transporters | Neurotransmitter Transporters | Cell Signaling | Protein Trafficking

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-401 was sufficient for detection of SNAT1 in 20 µg of lysates from neocortical neurons cultured under amino acid starvation conditions and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000) ; optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Hatanaka T., et al. ( 2000) Biochim. Biophys. Acta 1467: 1-6. 2. Wang H., et al. (2000) Biochem. Biophys. Res. Commun. 273: 1175-1179. 3. Gu S., et al. (2001) J. Biol. Chem. 276: 24137-24144. 4. Freeman T.L., et al. (2002) Arch. Biochem. Biophys. 400: 215-222. 5. Palii S.S., et al. (2004) J. Biol. Chem. 279: 3463-3471. 6. Sidoryk M., et al. (2004) Neuroreport. 15: 575-578. Erratum in: 2004. Neuroreport. 15: 533. 7. Desforges,M., et al. (2006) Am. J. Physiol. Cell. Physiol. 290: 305-312.

Shipping Conditions

Blue Ice or 4°C

Storage Conditions

-20ºC

Specificity

Detects ~50kDa.

Background Reference 01

1. Hatanaka T., et al. (2000) Biochim. Biophys. Acta 1467: 1-6. 2. Wang H., et al. (2000) Biochem. Biophys. Res. Commun. 273: 1175-1179. 3. Gu S., et al. (2001) J. Biol. Chem. 276: 24137-24144. 4. Freeman T.L., et al. (2002) Arch. Biochem. Biophys. 400: 215-222. 5. Palii S.S., et al. (2004) J. Biol. Chem. 279: 3463-3471. 6. Sidoryk M., et al. (2004) Neuroreport. 15: 575-578. Erratum in: 2004. Neuroreport. 15: 533. 7. Desforges, M., et al. (2006) Am. J. Physiol. Cell. Physiol. 290: 305-312.