Sodium Iodide Symporter Antibody, Clone 14F: RPE

The Sodium Iodide Symporter (NIS), encoded by the SLC5A5 gene, is a transmembrane glycoprotein responsible for actively transporting iodide ions into thyroid epithelial cells. This iodide uptake is a critical first step in the biosynthesis of thyroid hormones—triiodothyronine (T3) and thyroxine (T4) —which are essential regulators of metabolism, development, and neural function. While NIS is traditionally studied in the context of thyroid physiology and thyroid cancer imaging, emerging research highlights its broader relevance in neuroscience. Thyroid hormones play a pivotal role in brain development, synaptic plasticity, and neuroprotection. Dysregulation of NIS-mediated iodide transport can impair thyroid hormone synthesis, potentially contributing to cognitive decline, mood disorders, and neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Recent studies suggest that altered NIS expression or function may influence local thyroid hormone availability in the brain, affecting neuronal energy metabolism and oxidative stress responses. These findings position NIS as a potential biomarker and therapeutic target in neurodegenerative disease research. Understanding the role of NIS in the neuroendocrine axis opens new avenues for exploring how peripheral thyroid dysfunction may drive central nervous system pathology.

1 µg/ml of SMC-390 was sufficient for detection of hNIS in 20 µg of transfected COS-7 cell membrane lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

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1. Dai G., Levy O., Carrasco N. (1996) Nature. 379 (6564) : 458-460. 2. Snabik P.A., et al. (1997) Endocrin. 138 (8) : 3555-3558. 3. Dohan O., et al. (2007) Proc Natl Acad Sci USA. 104 (51) : 20250-20255.