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GABAA Receptor Alpha 1 Antibody, Clone N95/35: FITC

Mouse Anti-Human GABAA Receptor Alpha 1 Monoclonal IgG2a

Product Specifications

Background

The GABA A receptor alpha 1 subunit (GABRA1) is a critical component of the GABA A receptor complex, a family of fast-acting ligand-gated ion channels that mediate the majority of rapid inhibitory neurotransmission in the central nervous system. These receptors are pentameric structures composed of various subunits, with the alpha 1 subunit being the most abundantly expressed in the adult brain. GABRA1 plays a central role in maintaining synaptic inhibition, regulating neuronal excitability, and shaping network oscillations essential for cognitive and behavioral functions. Emerging evidence links GABRA1 dysfunction to the pathophysiology of several neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. Altered expression or function of the alpha 1 subunit has been associated with key features of neurodegeneration, such as disrupted inhibitory signaling, synaptic imbalance, and increased neuronal vulnerability. As such, GABRA1 is gaining attention as a potential biomarker and therapeutic target in the early detection and treatment of these disorders. Advancements in molecular imaging, transcriptomics, and electrophysiology are enhancing our understanding of GABRA1’s spatial distribution and functional dynamics in both healthy and diseased brains. These insights are crucial for developing targeted interventions aimed at restoring inhibitory tone and preserving neural circuitry in neurodegenerative conditions.

Specifications

Detects ~55kDa. No cross-reactivity against GABA-A-R-Alpha 2 or –Alpha3.

Product Name Alternative

ECA4, EJM, EJM5, GABA receptor alpha 1 polypeptide, GABA (A) receptor, GABA (A) receptor subunit alpha 1, GABA (A) receptor subunit alpha-1, GABA (A) receptor, alpha 1, GABRA 1, GABRA1, Gamma aminobutyric acid (GABA) A receptor alpha 1, Gamma aminobutyric acid A receptor alpha 1, Gamma aminobutyric acid receptor subunit alpha 1, Gamma-aminobutyric acid receptor subunit alpha-1, GBRA1_HUMAN

Synonyms

GABA A Receptor Alpha-1 Antibody, Clone N95/35: FITC

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

14394

Swiss Prot

P14867

Accession Number

NP_034380.1

Cellular Locus

Cell Membrane | Cell Junction | Synapse | Postsynaptic Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 355-394 of human GABA-A-R-Alpha1

Target

GABA A Receptor

Clonality

Monoclonal

Isotype

IgG2A

Clone

N95/35 (Formerly sold as S95-35)

Conjugation

FITC

Type

Monoclonal

Applications

WB | IHC | ICC/IF | AM

Validated Applications

IHC,ICC/IF

Field of Research

Neuroscience | Neurotransmitter Receptors | GABA Receptors | GABAA Receptors

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-346 was sufficient for detection of alpha1 GABA receptor in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136. 2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Product Datasheet

https://www.stressmarq.com/wp-content/uploads/2015/05/FITC-Fluorescent-conjugate.pdf

Product MSDS

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Specificity

Detects ~55kDa. No cross-reactivity against GABA-A-R-Alpha 2 or –Alpha3.

Background Reference 01

1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136. 2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602.

Species

Human | Mouse | Rat

CAS Number

9007-83-4

Location

Cell Membrane | Cell Junction | Synapse | Postsynaptic Cell Membrane

Isotype

IgG2A

Immunogen Species

Human

Curated Selection

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