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GABAA Receptor Delta Antibody, Clone N151/3: RPE

Mouse Anti-Rat GABAA Receptor Delta Monoclonal IgG2a

Product Specifications

Background

The GABA-A receptor delta subunit (GABRD) is a specialized component of the GABA-A receptor family, which comprises fast-acting ligand-gated ion channels responsible for inhibitory neurotransmission in the brain. Unlike synaptic GABA-A receptors, delta-containing receptors are primarily located extrasynaptically and mediate tonic inhibition—providing a continuous inhibitory tone that stabilizes neural networks and prevents hyperexcitability. GABRD is highly expressed in brain regions involved in cognition and emotional regulation, such as the thalamus, hippocampus, and cerebellum. Its unique role in maintaining baseline inhibitory control makes it a critical factor in neurological health. Dysregulation of GABRD has been implicated in a range of disorders, including epilepsy, anxiety, and sleep disturbances. More recently, its involvement in neurodegenerative diseases has gained attention, particularly in conditions like Alzheimer’s disease, where impaired tonic inhibition contributes to network dysfunction, excitotoxicity, and cognitive decline. Targeting GABRD-containing receptors offers a promising therapeutic strategy for restoring inhibitory balance and protecting against neurodegeneration. As research advances, GABRD is emerging as both a biomarker and a molecular target in the development of precision treatments for GABAergic dysfunction in aging and disease.

CAS Number

9007-83-4

Specifications

Detects ~55kDa.

Product Name Alternative

GABAA-RD, GABRD, MGC105467, Gamma-aminobutyric acid receptor subunit delta, GABA (A) receptor subunit delta, GBRD_HUMAN

Synonyms

GABA A Receptor Delta Antibody, Clone N151/3: RPE

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

29689

Swiss Prot

P18506

Accession Number

NP_058985.1

Cellular Locus

Cell Membrane | Cell Junction | Synapse | Postsynaptic Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide amino acids 15-34 (N-terminus) of rat GABA-A-R-Delta

Target

GABA A Receptor

Clonality

Monoclonal

Isotype

IgG2a

Clone

N151/3 (Formerly sold as S151-3)

Conjugation

RPE

Type

Monoclonal

Applications

WB | ICC/IF | AM

Validated Applications

WB,IHC,ICC/IF

Field of Research

Neuroscience | Neurotransmitter Receptors | GABA Receptors | GABAA Receptors

Purification

Protein G Purified

Limit Of Detection

2 µg/ml of SMC-345 was sufficient for detection of Delta1 GABA-A receptor in 10 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136. 2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Product Datasheet

https://www.stressmarq.com/wp-content/uploads/2015/05/R-PE-Fluorescent-conjugate.pdf

Product MSDS

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Specificity

Detects ~55kDa.

Background Reference 01

1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136. 2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602.

Species

Human | Mouse | Rat

Location

Cell Membrane | Cell Junction | Synapse | Postsynaptic Cell Membrane

Isotype

IgG2a

Immunogen Species

Rat

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