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TrpC7 Antibody: ATTO 488

Mouse Anti-Human TrpC7 Monoclonal IgG1

Product Specifications

Background

Transient receptor potential cation channel, subfamily C, member 7, also known as TRPC7, is a non-selective cation channel that is directly activated by DAG. TrpC7 shows constitutive activity and susceptibility to negative regulation by extracellular Ca2+. Because of this, TrpC7 plays an important role in the Ca2+ signaling pathway (1). TrpC7 is also expressed abundantly in the heart, and combined with its ability to act as a Ca2+ channel, TrpC7 might contribute to the process of heart failure (2).

Specifications

Detects ~100kDa.

Product Name Alternative

TRP7 Antibody, KNP3 Antibody, TRPM2 Antibody, transient receptor potential cation channel subfamily C member 7 Antibody

Synonyms

TRPC7 Antibody, Clone N64A/36: ATTO 488

UNSPSC

12352203

Gene ID

57113

Swiss Prot

Q9HCX4

Accession Number

NP_065122.1

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide amino acids 845-862 of human TRPC7

Target

TRPC7

Clonality

Monoclonal

Isotype

IgG1

Clone

N64A/36 (Formerly sold as S64A-36)

Conjugation

ATTO 488

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-343 was sufficient for detection of TrpC7 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Numaga T., Wakamori M., and Mori Y. (2007) Handb Exp Pharmacol. 179: 143-151. 2. Satoh S., et al. (2007) Mol Cell Biochem. 294(1-2): 205-215.

Product Datasheet

https://cdn.gentaur.com/products/400/4290197/datasheet/smc-343d-a488.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4290197/msds/smc-343d-a488.pdf

CAS Number

9007-83-4

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