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CRY1 Antibody

Product Specifications

Background

Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL

NCBI Gene ID

12952

Swiss Prot

Q16526

Accession Number

NP_031797.1

Host

Rabbit

Reactivity

Mouse

Immunogen

CRY1 antibody was raised against a peptide sequence around aa.551~555 (S-Q-G-S-G) derived from Mouse CRY1.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

1 mg/mL

Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store antibody at -20˚ C for up to one year.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=79-637

Calculated Molecular Weight

60 kDa

Specificity

This antibody detects endogenous level of total CRY1 protein.

Applications Notes

Western Blot: 1:500~1:1000

Symbol

Cry1

NCBI Official Name

Cryptochrome 1 (photolyase-like)

NCBI Organism

This antibody was raised against a peptide sequence around aa.551~555 (S-Q-G-S-G) derived from Mouse CRY1.

Background Reference 01

Morioka N, et al. (2010) J Pharmacol Sci. 113 (3) : 234-45. Fonseca F, et al. (2010) Mol Diagn Ther. 14 (3) : 171-8. Stratmann M, et al. (2010) Genes Dev. 24 (12) : 1317-28.

Other Product Names

Phll1, AU020726, AU021000, PHLL1

Tested Applications

WB

Protein ID

6681031

Physical Properties

Liquid

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