Nav1.8 Antibody, Clone S134

Mouse Anti-Rat Nav1.8 Monoclonal IgG2a

Product Specifications

Background

Nav1.8 is a tetrodotoxin-resistant voltage-gated sodium channel encoded by the SCN10A gene and is selectively expressed in peripheral sensory neurons, particularly nociceptors. It is critical for the transmission of noxious stimuli and contributes to the upstroke of action potentials in pain pathways. Nav1.8 is implicated in inflammatory and neuropathic pain, and its selective expression outside the central nervous system makes it a promising target for analgesic development. Unlike other sodium channels, Nav1.8 remains active at lower temperatures, supporting its role in cold-induced pain. While not directly linked to central neurodegeneration, chronic pain and peripheral nerve dysfunction are increasingly recognized as contributors to cognitive decline and neuroinflammation. Targeting Nav1.8 may therefore have indirect benefits in managing neurodegenerative disease symptoms.

CAS Number

9007-83-4

Specifications

Detects ~220kDa. No cross reactivity against other Nav channels.

Product Name Alternative

Nav1.8, SCN10A, Scn10a, PN3, mPN3, Sns, SNS, Peripheral nerve sodium channel 3, Pn3 (gene name), Sensory neuron sodium channel, Sodium channel protein type 10 subunit alpha, Sodium channel protein type X alpha subunit, Voltage-gated sodium channel alpha subunit Nav1.8

Synonyms

Nav1.8 Antibody, Clone S134

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

29571

Swiss Prot

Q62968

Accession Number

NP_058943.1

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat,Monkey

Immunogen

Fusion protein amino acids 1724-1956 of rat Nav1.8

Target

Nav1.8

Clonality

Monoclonal

Isotype

IgG2a

Clone

S134

Conjugation

Unconjugated

Type

Recombinant Monoclonal

Applications

WB | IHC | ICC/IF | AM

Validated Applications

WB,IHC,ICC/IF,AM

Field of Research

Neuroscience | Ion Channels | Sodium Channels | Voltage-Gated Sodium Channels

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-342 was sufficient for detection of Nav1.8 in 10 µg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Dray A. (2008) Br. J. Anaesth. 101(1): 48-58. 2. Dray A., Read S.J (2007) Arthritis Res. Ther. 9(3): 212. 3. Samuels M.E., teMorshe R.H., Lynch M.E., Drenth J.P. (2008) Mol Pain. 4: 21.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects ~220kDa. No cross reactivity against other Nav channels.

Background Reference 01

1. Dray A. (2008) Br. J. Anaesth. 101 (1) : 48-58. 2. Dray A., Read S.J (2007) Arthritis Res. Ther. 9 (3) : 212. 3. Samuels M.E., teMorshe R.H., Lynch M.E., Drenth J.P. (2008) Mol Pain. 4: 21.