Quisqualic acid

Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica[1][2].

Product Specifications

CAS Number

[52809-07-1]

Product Name Alternative

L-Quisqualic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR; mGluR

Type

Natural Products

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/quisqualic-acid.html

Purity

98.0

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)[C@@H](N)CN(C(N1)=O)OC1=O

Molecular Formula

C5H7N3O5

Molecular Weight

189.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Hugues-Olivier Bertrand, et al. Common and Selective Molecular Determinants Involved in Metabotopic Glutamate Receptor Agonist Activity. J Med Chem. 2002 Jul 18;45 (15) :3171-83.|[2]H Bräuner-Osborne, et al. Ligands for Glutamate Receptors: Design and Therapeutic Prospects. J Med Chem. 2000 Jul 13;43 (14) :2609-45.