Concanamycin B
Concanamycin B is a macrolide antibiotic, which can inhibit the cavitation type H+-ATPases, and the IC50 value is 5 nM[1].
Product Specifications
CAS Number
81552-33-2
Product Name Alternative
MCH 210
UNSPSC
12352005
Target
Antibiotic; Proton Pump
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/concanamycin-b.html
Solubility
10 mM in DMSO
Smiles
O=C1O[C@H]([C@@H](C)[C@@H](O)[C@@H]([C@@]2(O)C[C@@H](O[C@H]3C[C@H]([C@@H]([C@@H](C)O3)OC(N)=O)O)[C@H](C)[C@@H](/C=C/C)O2)C)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)\C=C1/O
Molecular Formula
C44H71NO14
Molecular Weight
838.03
References & Citations
[1]Yilla M, et al. Involvement of the vacuolar H (+) -ATPases in the secretory pathway of HepG2 cells. J Biol Chem. 1993 Sep 5;268 (25) :19092-100. PMID: 8395529.|[2]Woo JT, et al. Inhibition of the acidification of endosomes and lysosomes by the antibiotic concanamycin B in macrophage J774. Eur J Biochem. 1992 Jul 1;207 (1) :383-9.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Macrolide
Frequently Asked Questions
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