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Concanamycin B

Concanamycin B is a macrolide antibiotic, which can inhibit the cavitation type H+-ATPases, and the IC50 value is 5 nM[1].

Product Specifications

CAS Number

[81552-33-2]

Product Name Alternative

MCH 210

UNSPSC

12352005

Target

Antibiotic; Proton Pump

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/concanamycin-b.html

Solubility

10 mM in DMSO

Smiles

O=C1O[C@H]([C@@H](C)[C@@H](O)[C@@H]([C@@]2(O)C[C@@H](O[C@H]3C[C@H]([C@@H]([C@@H](C)O3)OC(N)=O)O)[C@H](C)[C@@H](/C=C/C)O2)C)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)\C=C1/O

Molecular Formula

C44H71NO14

Molecular Weight

838.03

References & Citations

[1]Yilla M, et al. Involvement of the vacuolar H (+) -ATPases in the secretory pathway of HepG2 cells. J Biol Chem. 1993 Sep 5;268 (25) :19092-100. PMID: 8395529.|[2]Woo JT, et al. Inhibition of the acidification of endosomes and lysosomes by the antibiotic concanamycin B in macrophage J774. Eur J Biochem. 1992 Jul 1;207 (1) :383-9.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Macrolide

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