GluN2B (NR2B, NMDA Receptor 2B) Antibody, Clone S59

Mouse Anti-Rat GluN2B Monoclonal IgG2b

Product Specifications

Background

NR2B (GRIN2B) is a subunit of the NMDA receptor complex, predominantly expressed during early brain development and in specific regions of the adult brain such as the hippocampus and cortex. NR2B-containing NMDA receptors exhibit slower deactivation kinetics and higher calcium permeability, making them critical for synaptic plasticity, memory formation, and neurodevelopment. In neurodegenerative disease research, NR2B has been implicated in excitotoxicity, a pathological process driven by excessive glutamate signaling and calcium influx. Overactivation of NR2B-containing receptors contributes to neuronal injury in conditions such as Alzheimer’s disease, Parkinson’s disease, and stroke. Pharmacological modulation of NR2B has shown promise in preclinical models for reducing neurotoxicity and improving cognitive function. NR2B-selective antagonists are being explored as therapeutic agents for neuroprotection and symptom management in neurodegenerative and neuropsychiatric disorders. Its developmental regulation and synaptic specificity make NR2B a valuable target for precision neuroscience.

CAS Number

9007-83-4

Specifications

Detects ~166kDa. No cross-reactivity against NR2A.

Product Name Alternative

NMDAR2B, hNR3, MGC142180, glutamate receptor subunit epsilon-2, NR3

Synonyms

GluN2B/NR2B Antibody, Clone S59

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

24410

Swiss Prot

Q00960

Accession Number

NP_036706.1

Cellular Locus

Cell Membrane | Cell Junction | Synapse | Postsynaptic Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 20-271 (extracellular N-terminus) of rat NR2B

Target

NR2B

Clonality

Monoclonal

Isotype

IgG2b

Clone

S59

Conjugation

Unconjugated

Type

Recombinant Monoclonal

Applications

WB | IHC | ICC/IF | IP | AM

Validated Applications

WB,IHC,ICC/IF,IP,AM

Field of Research

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-337 was sufficient for detection of NR2B in 10 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:100), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Zhuo M. (2009) Mol Brain. 2(1): 4 2. Gurwitz D, and Weizman A. (2002) Drug Discovery Today, 7(7): 403-406.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects ~166kDa. No cross-reactivity against NR2A.

Background Reference 01

1. Zhuo M. (2009) Mol Brain. 2 (1) : 4 2. Gurwitz D, and Weizman A. (2002) Drug Discovery Today, 7 (7) : 403-406.

Species

Human | Mouse | Rat

Location

Cell Membrane | Cell Junction | Synapse | Postsynaptic Cell Membrane

Isotype

IgG2b

Immunogen Species

Rat

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