Slo2.2 Antibody, Clone N3/26: HRP

Mouse Anti-Rat Slo2.2 Monoclonal IgG1

Product Specifications

Background

Slo2.2, a member of the Slo potassium channel family, is a sodium-activated potassium channel that contributes to the regulation of resting membrane potential and neuronal excitability. Unlike Slo1, Slo2.2 is activated by intracellular Na⁺ and Cl⁻, linking its activity to ionic homeostasis and metabolic state. This channel is thought to stabilize neuronal firing under conditions of high activity or metabolic stress, making it a potential modulator of excitotoxicity—a key feature of many neurodegenerative diseases. By dampening excessive excitability, Slo2.2 may protect neurons from calcium overload and oxidative damage. Although still under investigation, emerging evidence suggests that Slo2.2 dysfunction may contribute to the pathophysiology of epilepsy, ischemia, and neurodegenerative disorders such as ALS and Alzheimer’s disease. Its unique activation profile and role in maintaining neuronal stability position Slo2.2 as a novel target for neuroprotective strategies.

CAS Number

9007-83-4

Specifications

Detects ~140kDa. Weak human detection. Does not cross-react with KCNT2/Slo2.1/Slick.

Product Name Alternative

KCNT1, potassium channel subfamily T member 1, bA100C15.2, SLACK, KCa4.1, KIAA1422, FLJ41282

Synonyms

Slo2.2 Antibody, Clone N3/26: HRP

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

60444

Swiss Prot

Q9Z258

Accession Number

NP_068625

Cellular Locus

Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 1168-1237 of rat Slo2.2 (Slack)

Target

Slo2.2

Clonality

Monoclonal

Isotype

IgG1

Clone

N3/26 (Formerly sold as S3-26)

Conjugation

HRP

Type

Monoclonal

Applications

WB | IHC | ICC/IF | AM

Validated Applications

WB,IHC,ELISA

Field of Research

Neuroscience | Ion Channels | Potassium Channels | Calcium-Activated Potassium Channels

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-323 was sufficient for detection of Slo2.2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.