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Slo2.2 Antibody, Clone N3/26: ATTO 488

Mouse Anti-Rat Slo2.2 Monoclonal IgG1

Product Specifications

Background

Slo2.2, a member of the Slo potassium channel family, is a sodium-activated potassium channel that contributes to the regulation of resting membrane potential and neuronal excitability. Unlike Slo1, Slo2.2 is activated by intracellular Na⁺ and Cl⁻, linking its activity to ionic homeostasis and metabolic state. This channel is thought to stabilize neuronal firing under conditions of high activity or metabolic stress, making it a potential modulator of excitotoxicity—a key feature of many neurodegenerative diseases. By dampening excessive excitability, Slo2.2 may protect neurons from calcium overload and oxidative damage. Although still under investigation, emerging evidence suggests that Slo2.2 dysfunction may contribute to the pathophysiology of epilepsy, ischemia, and neurodegenerative disorders such as ALS and Alzheimer’s disease. Its unique activation profile and role in maintaining neuronal stability position Slo2.2 as a novel target for neuroprotective strategies.

Specifications

Detects ~140kDa. Weak human detection. Does not cross-react with KCNT2/Slo2.1/Slick.

Product Name Alternative

KCNT1, potassium channel subfamily T member 1, bA100C15.2, SLACK, KCa4.1, KIAA1422, FLJ41282

Synonyms

Slo2.2 Antibody, Clone N3/26: ATTO 488

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

60444

Swiss Prot

Q9Z258

Accession Number

NP_068625

Cellular Locus

Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 1168-1237 of rat Slo2.2 (Slack)

Target

Slo2.2

Clonality

Monoclonal

Isotype

IgG1

Clone

N3/26 (Formerly sold as S3-26)

Conjugation

ATTO 488

Type

Monoclonal

Applications

WB | IHC | ICC/IF | AM

Validated Applications

IHC,ICC/IF

Field of Research

Neuroscience | Ion Channels | Potassium Channels | Calcium-Activated Potassium Channels

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-323 was sufficient for detection of Slo2.2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Santi C.M., et al. (2006) J Neuroscience, 26(19): 5059-5068. 2. Yuan A., et al. (2003) Neuron 37: 765-773.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Product Datasheet

https://www.stressmarq.com/wp-content/uploads/2015/05/ATTO-488-Fluorescent-conjugate.pdf

Product MSDS

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Specificity

Detects ~140kDa. Weak human detection. Does not cross-react with KCNT2/Slo2.1/Slick.

Background Reference 01

1. Santi C.M., et al. (2006) J Neuroscience, 26 (19) : 5059-5068. 2. Yuan A., et al. (2003) Neuron 37: 765-773.

Species

Human | Mouse | Rat

CAS Number

9007-83-4

Location

Cell Membrane

Isotype

IgG1

Immunogen Species

Rat

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