TRPM7 Antibody, Clone S74

Transient Receptor Potential Melastatin 7 (TRPM7) is a unique bifunctional protein that combines an ion channel with an α-kinase domain, enabling it to regulate both ionic homeostasis and intracellular signaling. As a divalent cation-permeable channel, TRPM7 is a key regulator of magnesium (Mg²⁺) and calcium (Ca²⁺) influx, essential for neuronal excitability, synaptic plasticity, and cell survival. TRPM7 is widely expressed in the central nervous system and plays a critical role in neuronal development, axonal outgrowth, and glial function. Its kinase activity further modulates cytoskeletal dynamics and gene expression, linking ion transport to broader cellular responses. Dysregulation of TRPM7 has been implicated in several neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS) . In models of ischemia and excitotoxicity, TRPM7 overactivation leads to excessive Ca²⁺ influx, oxidative stress, and neuronal death—hallmarks of neurodegeneration. Moreover, TRPM7-mediated Mg²⁺ dysregulation has been associated with impaired mitochondrial function and neuroinflammation, further contributing to disease progression. Given its dual role in ion transport and kinase signaling, TRPM7 represents a promising therapeutic target in neurodegenerative disease research. Ongoing studies are exploring TRPM7 inhibitors and modulators as potential neuroprotective agents aimed at restoring ionic balance and preventing neuronal loss.

CHAK, CHAK1, Channel kinase 1, Channel-kinase 1, Long transient receptor potential channel 7, LTrpC-7, LTRPC7, Transient receptor potential cation channel subfamily M member 7, TRP PLIK, TRPM7, TRPM7_HUMAN

Neuroscience | Ion Channels | Transient Receptor Potential (TRP) Channels | Neuroscience | Neurodegeneration | Parkinson's Disease | ALS Disease | Alzheimer's Disease

1 µg/ml of SMC-316 was sufficient for detection of TrpM7 in 10 µg of COS cell lysate transiently transfected with TprM7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

1. Brauchi S., Krapivinsky G., Krapivinsky L., Clapham D.E. (2008) Proc Natl Acad Sci USA. 105(24): 8304-8308. 2. Numata T, Okada Y. (2008) J Biol Chem. 283(22): 15097-15103.

1. Brauchi S., Krapivinsky G., Krapivinsky L., Clapham D.E. (2008) Proc Natl Acad Sci USA. 105 (24) : 8304-8308. 2. Numata T, Okada Y. (2008) J Biol Chem. 283 (22) : 15097-15103.