Nav1.7 Antibody, Clone N68/6

Mouse Anti-Human Nav1.7 Monoclonal IgG1

Product Specifications

Background

Nav1.7 is a voltage-gated sodium channel encoded by the SCN9A gene and is predominantly expressed in peripheral sensory neurons. It plays a pivotal role in pain perception by amplifying subthreshold stimuli and facilitating action potential initiation. Loss-of-function mutations in Nav1.7 result in congenital insensitivity to pain, while gain-of-function mutations are associated with chronic pain syndromes. Importantly, Nav1.7 is not expressed in cardiac or central neurons, making it an attractive target for pain therapeutics with minimal off-target effects. Although primarily studied in nociception, emerging research suggests that peripheral nerve dysfunction and chronic pain may contribute to neurodegenerative disease burden. Nav1.7 inhibitors are under investigation as next-generation analgesics with potential applications in neurodegenerative conditions involving neuropathic pain.

CAS Number

9007-83-4

Specifications

Detects ~230kDa. No cross-reactivity against other Nav channels.

Product Name Alternative

Nav1.7, SCN9A, ETHA, hNE Na, NE NA, PN1, Voltage gated sodium channel subunit alpha Nav1, Peripheral sodium channel 1, Neuroendocrine sodium channel

Synonyms

Nav1.7 Antibody, Clone N68/6

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

6335

Swiss Prot

Q15858

Accession Number

NP_002968.1

Cellular Locus

Membrane | Synapse

Host

Mouse

Species Reactivity

Human,Mouse,Rat,Hamster

Immunogen

Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7

Target

Nav1.7

Clonality

Monoclonal

Isotype

IgG1

Clone

N68/6 (Formerly sold as S68-6)

Conjugation

Unconjugated

Type

Monoclonal

Applications

WB | IHC | ICC/IF | IP | AM

Validated Applications

WB,IHC,ICC/IF,IP,AM

Field of Research

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-314 was sufficient for detection of Nav1.7 in 10 µg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Dray A. (2008) Br. J. Anaesth. 101(1): 48-58. 2. Dray A., Read S.J (2007) Arthritis Res. Ther. 9(3): 212. 3. Samuels M.E., teMorshe R.H., Lynch M.E., Drenth J.P. (2008) Mol Pain. 4: 21.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects ~230kDa. No cross-reactivity against other Nav channels.

Background Reference 01

1. Dray A. (2008) Br. J. Anaesth. 101 (1) : 48-58. 2. Dray A., Read S.J (2007) Arthritis Res. Ther. 9 (3) : 212. 3. Samuels M.E., teMorshe R.H., Lynch M.E., Drenth J.P. (2008) Mol Pain. 4: 21.