Cav1.2 Antibody, Clone S57: ATTO 390

Cav1.2, encoded by the CACNA1C gene, is a major subunit of the L-type voltage-gated calcium channel family, best known for its role in cardiac excitation-contraction coupling. However, beyond the heart, Cav1.2 is highly expressed in the brain, where it regulates calcium influx critical for neuronal excitability, synaptic plasticity, and gene transcription. Dysregulation of Cav1.2 has been implicated in a range of neurological and neuropsychiatric disorders. Mutations in CACNA1C are causally linked to Timothy syndrome, a rare multisystem disorder characterized by cardiac arrhythmias, autism spectrum features, and cognitive impairment. Additionally, variants in CACNA1C have been associated with Brugada syndrome and are increasingly recognized as genetic risk factors for bipolar disorder, schizophrenia, and major depressive disorder. In the context of neurodegenerative disease, altered Cav1.2 function may contribute to disrupted calcium homeostasis, oxidative stress, and neuronal vulnerability—hallmarks of conditions such as Alzheimer’s and Parkinson’s disease. Its role in activity-dependent gene expression also positions Cav1.2 as a key modulator of long-term neuronal survival and plasticity. Given its dual importance in cardiac and neural physiology, Cav1.2 is a promising target for therapeutic strategies aimed at restoring calcium signaling balance in both neurodevelopmental and neurodegenerative disorders.

Voltage-dependent L-type calcium channel subunit alpha-1C, Cav1.2, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, Voltage-gated calcium channel subunit alpha Cav1.2, DHPR alpha-1 subunit, CACH3, CACN4, CACNL1A2, alpha-1 subunit voltage-dependent calcium channel, calcium channel voltage-dependent L type alpha 1C subunit1, calcium channel L type, alpha 1 polypeptide isoform 1 cardiac muscle, calcium channel cardiac dihydropyridine-sensitive alpha-1 subunit, voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit splice variant 10

1 µg/ml of SMC-300 was sufficient for detection of Cav1.2 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

1. Splawski I., et al. (2004) Cell. 119 (1): 19-31. 2. Krey J.F., and Dolmetsch R. (2009) Biophysical. 96 (3): 221a-222a. 3. Crotti L., Celano G., Dagradi F. and Schwartz P.J. (2008) Orphanet J Rare Disease 3:18.

1. Splawski I., et al. (2004) Cell. 119 (1) : 19-31. 2. Krey J.F., and Dolmetsch R. (2009) Biophysical. 96 (3) : 221a-222a. 3. Crotti L., Celano G., Dagradi F. and Schwartz P.J. (2008) Orphanet J Rare Disease 3:18.