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N-terminal Arginylation Antibody, Clone 11G1: PerCP

Mouse Anti-N-terminal Arginylation Monoclonal IgG3

Product Specifications

Background

N-terminal arginylation is a conserved post-translational modification that adds arginine residues to proteins, primarily via the action of arginyltransferase ATE1. This modification plays a pivotal role in embryonic development, cytoskeletal regulation, and cellular stress responses. In the context of neurodegeneration, N-terminal arginylation is essential for maintaining neuronal proteostasis and responding to endoplasmic reticulum and oxidative stress. It facilitates the degradation of misfolded proteins and modulates the actin cytoskeleton, both of which are critical for synaptic function and neuronal survival. Disruption of arginylation pathways has been linked to neurodevelopmental disorders and may contribute to the progression of diseases such as ALS and Alzheimer’s. As such, N-terminal arginylation represents a promising avenue for therapeutic exploration in neuroscience.

Specifications

Specific for N-terminal arginine, next to both glutamic acid and aspartic acid. Does not detect internal arginine.

Product Name Alternative

N-terminal Arginine, N-terminal Arginylation, N-terminal Arginylated, N terminal Arginine, N terminal Arginylation, N terminal Arginylated, Amino-terminal Arginine, Amino-terminal Arginylation, Amino-terminal Arginylated, Amino terminal Arginine, Amino terminal Arginylation, Amino terminal Arginylated

Synonyms

N-terminal Arginylation Antibody, Clone 11G1: PerCP

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Cellular Locus

Endoplasmic Reticulum

Host

Mouse

Species Reactivity

Species Independent

Immunogen

Synthetic N-terminal arginylated peptide conjugated to KLH

Target

N-terminal Arginylation

Clonality

Monoclonal

Isotype

IgG3

Clone

11G1

Conjugation

PerCP

Type

Monoclonal

Applications

WB

Validated Applications

WB,IHC,ICC/IF,ELISA

Field of Research

Cell Signaling | Post-translational Modifications | Arginylation

Purification

Protein G Purified

Limit Of Detection

A 1:1000 dilution of SMC-265 was sufficient for detection of N-terminal Arginylation in 0.5 ug of N-terminal Arginine peptide conjugated to BSA by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Saha S. and Kashina A. (2011) Dev Biol. 385(1): 1-8. 2. Deka K., et al. (2016) Cell Death Discov. 2: 16074.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Product Datasheet

https://www.stressmarq.com/wp-content/uploads/2015/05/PerCP-Fluorescent-conjugate.pdf

Product MSDS

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Specificity

Specific for N-terminal arginine, next to both glutamic acid and aspartic acid. Does not detect internal arginine.

Background Reference 01

1. Saha S. and Kashina A. (2011) Dev Biol. 385 (1) : 1-8. 2. Deka K., et al. (2016) Cell Death Discov. 2: 16074.

Species

Species Independent

CAS Number

9007-83-4

Location

Endoplasmic Reticulum

Isotype

IgG3

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