What is the catalog number for N-terminal Arginylation Antibody, Clone 4D12: Biotin?

The catalog number for N-terminal Arginylation Antibody, Clone 4D12: Biotin is SMC-264D-BI.

What sizes are available for N-terminal Arginylation Antibody, Clone 4D12: Biotin?

N-terminal Arginylation Antibody, Clone 4D12: Biotin is available in the following size(s): 100 µg.

Where can I find the safety data sheet (SDS/MSDS) for N-terminal Arginylation Antibody, Clone 4D12: Biotin?

The safety data sheet for N-terminal Arginylation Antibody, Clone 4D12: Biotin is available here: https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf.

N-terminal Arginylation Antibody, Clone 4D12: Biotin

Q: Is N-terminal Arginylation Antibody, Clone 4D12: Biotin in stock?

N-terminal Arginylation Antibody, Clone 4D12: Biotin is currently made to order / not held in immediate stock. Contact us for lead time.

Mouse Anti-N-terminal Arginylation Monoclonal IgG1

Product Specifications

Background

Protein arginylation, specifically at the N-terminus, is a critical post-translational modification mediated by the enzyme ATE1. This process regulates protein turnover, stress response, and cytoskeletal organization. In neurons, N-terminal arginylation facilitates the clearance of misfolded proteins and modulates actin dynamics, both essential for synaptic integrity and plasticity. Emerging evidence suggests that dysregulation of arginylation contributes to neurodegenerative pathologies by impairing proteostasis and enhancing susceptibility to cellular stress. Arginylation also influences the unfolded protein response and autophagy, linking it to mechanisms underlying Alzheimer’s and Huntington’s disease. As a regulator of neuronal resilience and intracellular signaling, N-terminal arginylation is gaining attention as a potential therapeutic target in neurodegeneration.

CAS Number

9007-83-4

Specifications

Specific for N-terminal arginine, next to both glutamic acid and aspartic acid. Does not detect internal arginine.

Product Name Alternative

N-terminal Arginine, N-terminal Arginylation, N-terminal Arginylated, N terminal Arginine, N terminal Arginylation, N terminal Arginylated, Amino-terminal Arginine, Amino-terminal Arginylation, Amino-terminal Arginylated, Amino terminal Arginine, Amino terminal Arginylation, Amino terminal Arginylated

Synonyms

N-terminal Arginylation Antibody, Clone 4D12: Biotin

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Cellular Locus

Endoplasmic Reticulum

Host

Mouse

Species Reactivity

Species Independent

Immunogen

Synthetic N-terminal arginylated peptide conjugated to KLH

Target

N-terminal Arginylation

Clonality

Monoclonal

Isotype

IgG1

Clone

4D12

Conjugation

Biotin

Type

Monoclonal

Applications

Validated Applications

WB,IHC,ICC/IF |ELISA

Field of Research

Cell Signaling | Post-translational Modifications | Arginylation

Purification

Protein G Purified

Limit Of Detection

A 1:1000 dilution of SMC-264 was sufficient for detection of N-terminal Arginylation in 0.5 ug of N-terminal Arginine peptide conjugated to BSA by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

136.36mM Ethanolamine, 133.23 mM Chlorides, 9.55mM Phosphates, 9.55mM Sodium Bicarbonate

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Saha S. and Kashina A. (2011) Dev Biol. 385(1): 1-8. 2. Deka K., et al. (2016) Cell Death Discov. 2: 16074.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Specificity

Specific for N-terminal arginine, next to both glutamic acid and aspartic acid. Does not detect internal arginine.

Background Reference 01

1. Saha S. and Kashina A. (2011) Dev Biol. 385 (1) : 1-8. 2. Deka K., et al. (2016) Cell Death Discov. 2: 16074.

Species

Species Independent

Location

Endoplasmic Reticulum

Isotype

IgG1

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

EK0689 96 Well With Removable Strips

Mouse CCL27/CTACK ELISA Kit PicoKine®

View Details

orb1009568 100 µL

SAPAP3 Rabbit Polyclonal Antibody (APC)

View Details

P0772-01 50 µg

Recombinant Human OLIG2

View Details

P0772-02 200 µg

Recombinant Human OLIG2

View Details

P0772-03 1 mg

Recombinant Human OLIG2

View Details

GTR15134122 1 Vial

Lentiviral human NXF3 shRNA (UAS) - Lentiviral human NXF3 shRNA (UAS, GFP) plasmid

View Details