CGRP antagonist 1
Product Specifications
UNSPSC Description
CGRP antagonist 1 (compound 21) is a highly potent CGRP receptor antagonist with a Ki and an IC50 of 1.7 nM and 5.7 nM, respectively[1].
Target Antigen
CGRP Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC2=C(C[C@@]3(C4=CC=CN=C4NC3=O)C2)C=C1)CN5C(C6(CCOCC6)C7=C5C=CC=C7)=O
Molecular Weight
494.54
References & Citations
[1]Stump CA, et al. The discovery of highly potent CGRP receptor antagonists. Bioorg Med Chem Lett. 2009 Jan 1;19(1):214-7.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112262/CGRP-antagonist-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112262/
Clinical Information
No Development Reported
CAS Number
1123757-49-2
Available Sizes
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