CGRP antagonist 1
CGRP antagonist 1 (compound 21) is a highly potent CGRP receptor antagonist with a Ki and an IC50 of 1.7 nM and 5.7 nM, respectively[1].
Product Specifications
CAS Number
[1123757-49-2]
UNSPSC
12352005
Target
CGRP Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/_S_-N-_2_acute_-Oxo-1,1_acute_,2_acute_,3-tetrahydrospiro-indene-2,3_acute_-pyrrolo-2,3-b-pyridin--5-yl_-2-_2-oxo-2_acute_,3_acute_,5_acute_,6_acute_-tetrahydrospiro-indoline-3,4_acute_-pyran--1-yl_acetamide.html
Purity
99.68
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC2=C(C[C@@]3(C4=CC=CN=C4NC3=O)C2)C=C1)CN5C(C6(CCOCC6)C7=C5C=CC=C7)=O
Molecular Formula
C29H26N4O4
Molecular Weight
494.54
References & Citations
[1]Stump CA, et al. The discovery of highly potent CGRP receptor antagonists. Bioorg Med Chem Lett. 2009 Jan 1;19 (1) :214-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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