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PP5 Antibody: RPE

Mouse Anti-Human PP5 Monoclonal IgG1

Product Specifications

Background

Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues, potentially playing a role in the regulation of cell growth and differentiation. PP5 or PPT is predominantly a nuclear protein and interacts with CDC16 and CDC27. It is found in association with several proteins that influence intracellular signlaing-cascades intitiated by hormones (glucocorticoids) or cellular stress (hypoxia, oxidative stress and DNA Damage). It phosphorylates serine residues of skeletal muscle phosphorylase and histone H1. It may also be involved in mitosis and RNA biogenesis regulation (1,2).

Specifications

Detects ~58kDa.

Product Name Alternative

PPP5 Antibody, PPT Antibody, Protein phosphatase T Antibody, Serine/threonine protein phosphatase 5 Antibody

Synonyms

PP5 Antibody, Clone 12F7: RPE

UNSPSC

12352203

Gene ID

5536

Swiss Prot

P53041

Accession Number

NP_006238.1

Cellular Locus

Nucleus | Cytoplasm

Host

Mouse

Species Reactivity

Human

Immunogen

Full length human PP5 protein

Target

PP5

Clonality

Monoclonal

Isotype

IgG1

Clone

12F7

Conjugation

RPE

Validated Applications

WB,IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-244 was sufficient for detection of PP5 in 15 µg of human A431 lysates by ECL analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Butzow R., et al. (1988) J Lab Clin Med. 111(2): 249-256.

Product Datasheet

https://cdn.gentaur.com/products/400/4288654/datasheet/smc-244d-rpe.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4288654/msds/smc-244d-rpe.pdf

CAS Number

9007-83-4

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