ENaC beta Antibody, Clone 7B8: APC

The beta subunit of the epithelial sodium channel (ENaCβ) is essential for the functional assembly and regulation of the ENaC complex, which governs sodium absorption across epithelial surfaces. While ENaCβ is well-characterized in renal and pulmonary physiology, its emerging role in the nervous system is drawing increasing interest in neurodegenerative disease research. ENaCβ is critical for fluid clearance in distal lung epithelia, particularly in response to edema, and its expression is upregulated during keratinocyte differentiation—highlighting its involvement in cellular stress adaptation. In the retina, ENaCβ is differentially expressed under conditions of ocular hypertension, suggesting a role in neurovascular regulation and intraocular pressure homeostasis. These mechanisms are relevant to neurodegenerative diseases where fluid imbalance, oxidative stress, and ion dysregulation contribute to neuronal injury. Recent studies propose that ENaCβ may influence glial cell function, neuroinflammation, and blood-brain barrier integrity—key factors in the progression of disorders such as Parkinson’s disease and ALS. As a regulator of sodium flux and tissue hydration, ENaCβ represents a promising target for modulating neuroimmune responses and preserving neural function. By bridging epithelial ion transport and neural health, ENaCβ offers a novel perspective in the search for biomarkers and therapeutic strategies in neurodegeneration.

Amiloride sensitive sodium channel subunit beta, Amiloride-sensitive sodium channel beta-subunit, Beta ENaC, Beta NaCH, ENaC beta, ENaCB, Epithelial Na (+) channel subunit beta, Epithelial Na+ channel beta subunit, Epithelial Na+ channel subunit beta, Epithelial sodium channel beta 2 subunit, Epithelial sodium channel beta 3 subunit, Nonvoltage gated sodium channel 1 beta subunit, Nonvoltage gated sodium channel 1 subunit beta, Nonvoltage-gated sodium channel 1 beta subunit, SCNEB, SCNN 1B, SCNN1B, Sodium channel nonvoltage gated 1 beta, Sodium channel nonvoltage gated 1 beta (Liddle syndrome)

A 1:1000 dilution of SMC-240 was sufficient for detection of ENaC beta in 15 µg of Mouse whole kidney lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

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1. Kakizoe Y., et al. (2009) J Hpyertens. 27 (8) : 1679-1689. 2. Gu Y. (2008) J Cell Physiol. 216 (2) :453-457. 3. Bruns J.B. (2003) Am J Physiol Renal Physiol. 285 (4) : F600-F609. 4. Mauro T., et al. (2002) J Invest Dermatol. 118 (4) : 589-594. 5. Elias N., et al. (2007) Am J Physiol Lung Cell Mol Physiol. 293 (3) : L537-45. 6. Dyka F.M., May C.A. and Enz R. (2005) J Neurochem. 94 (1) : 120-128.