GRP170 Antibody, Clone 6E3-2C3: PerCP

GRP170 (also known as ORP150) is the largest member of the glucose-regulated protein (GRP) family and functions as a critical endoplasmic reticulum (ER) chaperone. It plays a central role in protein folding and secretion, particularly under conditions of cellular stress such as hypoxia. This chaperone exhibits strong cytoprotective properties by suppressing apoptosis, making it vital for cell survival in stress-prone environments like the brain. In neurodegenerative diseases—where ER stress, hypoxia, and protein misfolding are common—GRP170’s protective functions are especially relevant. Beyond its role in proteostasis, GRP170 also contributes to immune modulation. It binds to dendritic cells and delivers danger signals that can trigger anti-tumor immune responses. This dual role in cellular protection and immune activation positions GRP170 as a promising therapeutic target in both oncology and neurodegeneration. Its emerging relevance in neuroscience stems from its ability to mitigate ER stress and support neuronal viability, suggesting potential applications in diseases such as Alzheimer’s, Parkinson’s, and ALS.

GRP170, HYOU1, HSP12A, HSPH4, ORP150, ORP-150, Orp150, Orp 150, Grp170, Grp 170, GRP-170, HSP 12A, Hypoxia up-regulated 1, Hypoxia up regulated 1, Hypoxia upregulated 1, hypoxia up-regulated 1 precursor, Hypoxia up-regulated protein 1, 150 kDa oxygen-regulated protein, 150kDa oxygen regulated, 170 kDa glucose-regulated protein, 170 kDa glucose regulated protein, glucose regulated protein 170, Glucose regulated 170, DKFZp686N08236, FLJ94899, FLJ97572, HYOU1_HUMAN, oxygen regulated protein (150kD)

Cancer | Heat Shock | Neuroscience | Neurodegeneration | Epigenetics and Nuclear Signaling | Cardiovascular System |Cell Signaling | Protein Trafficking | Chaperone Proteins | ER Proteins | Cancer | Invasion/microenvironment | Cancer | Cancer Metabolism | Response to Hypoxia | Cell Signaling | Metabolism | Metabolism processes | Hypoxia

1 µg/ml of SMC-232 was sufficient for detection of GRP170 in 20 µg of HEK293 lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.